Publications by authors named "Radu Vidra"
(1) Background: Following the results of RAINBOW and REGARD trials, ramucirumab was approved as the standard second-line treatment for patients with advanced or metastatic gastric or gastroesophageal junction (GEJ) cancer, alone or in combination with paclitaxel. The present study aimed to evaluate the efficacy and safety of ramucirumab in the Romanian population during every-day clinical practice. (2) Methods: A two-center, retrospective, observational study evaluated patients with metastatic gastric and GEJ cancer treated with ramucirumab monotherapy or associated with paclitaxel.
View Article and Find Full Text PDFPatients with cancer are a high-priority population for COVID-19 vaccination, as per guideline recommendations. The present cross-sectional study was performed to assess the perception of patients with cancer from Romania regarding COVID-19 vaccines. The study included 932 patients with solid and hematologic malignancies.
View Article and Find Full Text PDFSpectrum of BRCA1/2 Mutations in Romanian Breast and Ovarian Cancer Patients.
Int J Environ Res Public Health
April 2022
Article Synopsis
- Approximately 10,000 women are diagnosed with breast cancer and 2,000 with ovarian cancer each year in Romania, but there are few genetic studies focused on identifying high-risk patients in the population.
- Researchers evaluated 490 women (250 with breast cancer and 240 with ovarian cancer) using Next-Generation Sequencing to examine for harmful mutations in the BRCA1 and BRCA2 genes.
- The study found a significant number of patients with BRCA mutations: 47% of breast cancer patients and 25% of ovarian cancer patients, identifying specific mutation variants that could help in genetic testing and risk assessment in the Romanian population.*
Article Synopsis
- Fertility and pregnancy issues are crucial for young breast cancer patients, but there's limited understanding among physicians in low- and middle-income countries (LMICs) on these topics.
- A survey of 288 physicians revealed that many had never consulted international guidelines, and a significant portion felt uninformed about fertility preservation methods like cryopreservation.
- The results indicate a need for improved education and awareness among LMIC physicians regarding fertility preservation and pregnancy considerations for young breast cancer survivors.
Background: Covid-19 vaccination has started in the majority of the countries at the global level. Cancer patients are at high risk for infection, serious illness, and death from COVID-19 and need vaccination guidance and support. Guidance availability in the English language only is a major limit for recommendations' delivery and their application in the world's population and generates information inequalities across the different populations.
View Article and Find Full Text PDFThe addition of platinum compounds to standard neoadjuvant chemotherapy (NACT) for triple-negative breast cancer (TNBC) is highly controversial. Platinum agents, such as cisplatin and carboplatin, are DNA-damaging agents which exhibit activity in breast cancer, particularly in the TNBC subgroup. In order to assess the efficacy of each most representative platinum agent (cisplatin and carboplatin) in patients with TNBC treated with NACT, the present study performed a systematic review and meta-analysis of all available published studies on TNBC.
View Article and Find Full Text PDFChallenges of pancreatic cancer chemotherapy in the COVID-19 era.
J Gastrointestin Liver Dis
June 2020
The European Society for Medical Oncology (ESMO) is one of the leading societies of oncology professionals in the world. Approximately 30% of the 13 000 ESMO members are below the age of 40 and thus meet the society's definition of young oncologists (YOs). ESMO has identified the training and development of YOs as a priority and has therefore established a comprehensive career development programme.
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