Evaluation of the Alkaloids as Inhibitors of Human Acetylcholinesterase by Molecular Docking and ADME Prediction.

Background/aim: Alzheimer's disease is a complex, incurable to date, multifactorial disease, which suggests the need for continued development of pharmacotherapy.

Materials And Methods: A comprehensive literature search was conducted to identify known ligands with anticholinesterase activity, resulting in the discovery of over 100 alkaloids that are also available in the PubChem database. Subsequently, the ligands underwent molecular docking to evaluate their affinity for the target enzyme.

Competitive Electrochemical Apta-Assay Based on cDNA-Ferrocene and MXenes for Surface Protein A Detection.

() represents one of the most frequent worldwide causes of morbidity and mortality due to an infectious agent. It is a part of the infamous ESKAPE group, which is highly connected with increased rates of healthcare-associated infections and antimicrobial resistance. can cause a large variety of diseases.

Urinary biomonitoring of exposure to glyphosate and its metabolite amino-methyl phosphonic acid among farmers and non-farmers in Morocco.

Glyphosate, a widely used herbicide in global agriculture, poses potential health risks due to environmental and dietary exposure. This study evaluated urinary concentrations of glyphosate and its metabolite, amino-methyl phosphonic acid (AMPA), among farmers and non-farmers in Morocco's Fez-Meknes region, using liquid chromatography-tandem mass spectrometry. Glyphosate was detected in 57.

Custom-made 3D printed subperiosteal implant for restoration of severe atrophic jaw: A case report.

Key Clinical Message: Digital technology significantly enhances subperiosteal implantology by enabling precise presurgical planning based on CBCT scans. This technology reduces patient trauma and ensures optimal implant fit, presenting a promising alternative to traditional analogue methods.

Abstract: In the last decades, significant progress has been made in oral implantology, particularly with endosseous implants, primarily due to advancements brought about by the digital revolution.

Patient Centricity-An Empirical Research on Titanium Dental Implants and Their Adverse Effects on Health Condition.

Background/objectives: Titanium dental implants are considered to be the most modern and effective solution for replacing lost teeth. These medical devices not only restore the chewing and aesthetic functionality of the smile but also provide a stable support for crowns, bridges or dentures. The aim of this study was to identify the perceptions of patients about titanium dental implants and their effects on the human body.

Micropulse Laser Therapy in Central Serous Chorioretinopathy.

: Central serous chorioretinopathy (CSCR) is a retinal condition characterized by the accumulation of subretinal fluid, often linked to elevated levels of endogenous corticosteroids and stress-related hormones, which can lead to visual disturbances. This connection may explain the association of CSCR with high stress levels and the use of corticosteroid medications. Although many cases resolve spontaneously, persistent or severe instances may require intervention.

Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions.

Psoriasis represents a chronic autoimmune skin condition defined by various clinical forms, including inverse, erythrodermic, pustular, guttate, plaque types. While current therapies, including topical treatments but also systemic through conventional synthetic drugs and biologics, have improved symptom management, no treatment completely cures the disease, and numerous options are linked to considerable adverse effects, including immunosuppression and carcinogenic risks. Therefore, there is growing interest in bioactive compounds from natural sources due to their potential to reduce inflammation and oxidative stress in psoriasis with fewer adverse effects.

Association between pesticide exposure and end-stage renal disease: A case-control study from Morocco based on the STROBE guidelines.

Experimental studies have shown that various pesticides can damage kidney function, but epidemiological information on the effects of long-term low-level pesticide exposure is lacking. A study in Fez Meknes, Morocco, examined the link between 31 pesticides and end-stage renal disease (ESRD). This study involved 12 hemodialysis centers in various areas.

Deciphering the Intricate Interplay in the Framework of Antibiotic-Drug Interactions: A Narrative Review.

Drug interactions are a significant and integral part of the concept of medication-related adverse events, whether referring to potential interactions or those currently observed in real-world conditions. The high global consumption of antibiotics and their pharmacokinetic and pharmacodynamic mechanisms make antibiotic-drug interactions a key element that requires continuous study due to their clinical relevance. In the present work, the current state of knowledge on antibiotic-drug interactions, which are less studied than other drug-drug interactions despite their frequent use in acute settings, has been consolidated and updated.

How Morphology Shapes Survival in Invasive Squamous Cell Carcinoma of the Lung.

Background And Objectives: Squamous cell carcinoma (SQCC) represents a significant proportion of human malignancies affecting various anatomical sites, including the lung. Understanding the prognostic factors is crucial for establishing effective risk stratification in these patients, as multiple critical aspects significantly impact overall survival.

Materials And Methods: A retrospective study was conducted on 99 patients with operable lung SQCC treated at a tertiary center.

Polyphenols Investigation and Antioxidant and Anticholinesterase Activities of L. Species from Southwest Romania Flora.

Rosemary is one of the most important medicinal plants for natural therapy due to its multiple pharmacological properties, such as antioxidant, anti-inflammatory, neuroprotective, antiproliferative, antitumor, hepato- and nephroprotective, hypolipidemic, hypocholesterolemic, antihypertensive, anti-ischemic, hypoglycemic, radioprotective, antimicrobial, antiviral, antiallergic, and wound healing properties. Our study reports for the first time, over a 12-month period, the identification and quantification of polyphenols and the investigation of the antioxidant and acetylcholinesterase (AChE) inhibitory activities of the L. species harvested at flowering from the flora of southwestern Romania (Oltenia Region).

Superficial Vein Thrombosis in an Asymptomatic Case of Cholangiocarcinoma with Recent History of COVID-19.

The COVID-19 pandemic brought into prominence several emergent medical and surgical entities, but, also, it served as trigger and contributor for numerous apparently unrelated ailments such as arterial and venous thromboembolic complications. Additional risk factors for these thrombotic traits may be concurrent (known or unknown) malignancies, including at hepatic level. Among these, cholangiocarcinoma (CCA), a rare cancer of intra- and extra-hepatic biliary ducts, represents a very aggressive condition that typically associates local and distant advanced stages on first presentation requiring a prompt diagnosis and a stratified management.

Innovative Strategies for Upcycling Agricultural Residues and Their Various Pharmaceutical Applications.

This review investigates innovative strategies for upcycling agricultural residues into valuable pharmaceutical compounds. The improper disposal of agricultural residues contributes to significant environmental issues, including increased greenhouse gas emissions and ecosystem degradation. Upcycling offers a sustainable solution, transforming these residues into high-value bioproducts (antioxidants, antitumor agents, antidiabetic compounds, anti-inflammatory agents, and antiviral drugs).

Improving the Jump Shots of U12 Junior Basketball Players by Implementing a Combined Program of Plyometric and Coordination Exercises Using MyVert Technology.

The aim of this study was to investigate the impact of the implementation of an experimental program with combined plyometric and coordination exercises for a time interval of 6 months aimed at improving the jump shots of U12 junior players through the use of information technologies. One hundred seventeen female basketball players, aged between 10 and 12 years (U12), participated in this study. The study subjects were divided into two groups: the experimental group (EG), with 60 (51.

Healing of Extraction Sites after Alveolar Ridge Preservation Using Advanced Platelet-Rich Fibrin: A Retrospective Study.

Background: Over time, numerous surgical procedures and biomaterials have been proposed for the reconstruction of post-extraction bone defects, each with their advantages and disadvantages. The main objective of this study was to evaluate dimensional changes in the alveolar bone 3 months after tooth extraction, before implant planning, comparing alveolar ridge preservation (ARP) with spontaneous healing.

Methods: A total of 84 patients with non-restorable molars were included in the study.

Synergistic Combination of Aztreonam and Ceftazidime-Avibactam-A Promising Defense Strategy against OXA-48 + NDM in Romania.

Unlabelled: With the increasing burden of carbapenem-resistant (CR-Kp), including high rates of healthcare-associated infections, treatment failure, and mortality, a good therapeutic strategy for attacking this multi-resistant pathogen is one of the main goals in current medical practice and necessitates the use of novel antibiotics or new drug combinations.

Objectives: We reviewed the clinical and microbiological outcomes of seven patients treated at the "Agrippa Ionescu" Clinical Emergency Hospital between October 2023 and January 2024, aiming to demonstrate the synergistic activity of the ceftazidime-avibactam (C/A) plus aztreonam (ATM) combination against the co-producers of NDM + OXA-48-like CR-Kp.

Material And Methods: Seven CR-Kp with NDM and OXA-48 as resistance mechanisms were tested.

Pharmaceutical Applications of Biomass Polymers: Review of Current Research and Perspectives.

Polymers derived from natural biomass have emerged as a valuable resource in the field of biomedicine due to their versatility. Polysaccharides, peptides, proteins, and lignin have demonstrated promising results in various applications, including drug delivery design. However, several challenges need to be addressed to realize the full potential of these polymers.

Exploring a New Pathophysiological Association in Acne Vulgaris and Metabolic Syndrome: The Role of Biogenic Amines and Glutathione Peroxidase.

: Metabolic disorders cause many skin issues, including acne vulgaris. This research investigated the function of glutathione peroxidase (GTPx) and biogenic amines as a potential novel pathophysiological link between metabolic syndrome (MetS) and acne vulgaris. The patients were distributed into two groups: metabolic precondition (MPG, = 78) and control (CG, = 81).