Surgical Technique for Management of Congenital Pseudarthrosis of the Clavicle.

Congenital pseudarthrosis of the clavicle is a rare phenomenon with multiple proposed causes. Surgical management is typically indicated either because of the cosmetic appearance of the irregularity or, less commonly, for pain, particularly in adolescent patients. Multiple surgical methods have previously described in the literature, which have raised concern owing to the persistently high rate of nonunion postoperatively.

Staged Bilateral Total Knee Arthroplasty: Differing Results Comparing the First and Second Knees.

Background: Patients often prefer one knee over the other following staged bilateral total knee arthroplasty (BTKA). Our study compared patient-reported outcomes scores of each knee following BTKA and identified factors that may contribute to the identified discrepancies.

Methods: All patients who underwent staged BTKA between July 2014 and August 2022 were identified.

Early Radiographic and Clinical Outcomes of an Additive-Manufactured Acetabular Component.

Background: Additive manufacturing has recently gained popularity and is widely adopted in the orthopaedic industry. However, there is a paucity of literature on the radiographic and clinical outcomes of these relatively novel components. The aim of this study was to assess the 2-year clinical and radiographic outcomes of a specific additive-manufactured acetabular component in primary total hip arthroplasty.

Hemodynamics in arterial bypass graft anastomoses with varying cuff sizes and proximal flow paths: a fluid-structure interaction study.

This article investigates the effect of the cuff size of arterial bypass grafts and the flow conditions on the hemodynamics in the anastomosis (connection) to the artery, using numerical simulations. We consider a fluid-structure interaction problem which is solved based on a partitioned scheme. Additionally, we employ computational fluid dynamics to investigate the effect of a rigid wall assumption.

Outpatient Total Joint Arthroplasty at a High-Volume Academic Center: An Analysis of Failure to Launch.

Background: Unanticipated failure to discharge home (failure to launch, FTL) following scheduled same-day discharge (SDD) total joint arthroplasty (TJA) is problematic for the surgical facility with respect to staffing, care coordination, and reimbursement concerns. The aim of this study was to review rates, etiologies, and contributing factors for FTL in SDD TJA at an inpatient academic medical center.

Methods: All patients who underwent primary TJA between February 2021 and February 2023 were retrospectively reviewed.

CRISPR/Cas9-induced knockout reveals the role of ABCB1 in the response to temozolomide, carmustine and lomustine in glioblastoma multiforme.

Glioblastoma multiforme (GBM) is the most common malignant brain tumor with limited therapeutic options. Besides surgery, chemotherapy using temozolomide, carmustine or lomustine is the main pillar of therapy. However, therapy success is limited and prognosis still is very poor.

Does the use of chitosan covered gauze for postpartum hemorrhage reduce the need for surgical therapy including hysterectomy? A databased historical cohort study.

Objectives: Postpartum hemorrhage (PPH) is still one of the leading causes of maternal mortality worldwide. Recently effective PPH therapy with uterine packing with the chitosan-covered gauze was shown. This databased retrospective case-control study compares the therapy success of the chitosan tamponade with that of the balloon tamponade and medical therapy only.

The Contribution of Galenics to Patients' Sensory Perception of Nasal Sprays After Nasal Surgery: Data from a Prospective Randomised, Controlled, Double-Blind, Crossover, Multicentre Study.

Introduction: Postoperative care after nasal surgery is commonly achieved with nasal sprays. The current study compared two decongesting, wound-healing nasal sprays in patients after nasal surgery in order to investigate their sensory perception. One of the sprays was a new galenic formulation (nasic neo, Cassella-med GmbH & Co.

The Accuracy of Three-Dimensional CT Scan Software in Predicting Prosthetic Utilization in Total Shoulder Arthroplasty.

Introduction: Recent innovations in shoulder arthroplasty include three-dimensional (3D) CT software imaging that can be used to predict which prosthetic implants will be used intraoperatively. Correct prediction of the implants may optimize supply chain logistics for the surgeon, hospital, ambulatory surgery center, and the implant company. The purpose of this study was to examine a single surgeon's experience with this software to determine its predictive accuracy in determining which implants would be used intraoperatively.

Clinical Implications of Bone Bruise Patterns Accompanying Anterior Cruciate Ligament Tears.

Background: Anterior cruciate ligament (ACL) tears are common injuries; they are often associated with concomitant injuries to other structures in the knee, including bone bruises. While there is limited evidence that bone bruises are associated with slightly worse clinical outcomes, the implications of bone bruises for the articular cartilage and the risk of developing osteoarthritis (OA) in the knee are less clear. Recent studies suggest that the bone bruise pattern may be helpful in predicting the presence of meniscal ramp lesions.

Human Skin Microbiome: Impact of Intrinsic and Extrinsic Factors on Skin Microbiota.

The skin is the largest organ of the human body and it protects the body from the external environment. It has become the topic of interest of researchers from various scientific fields. Microorganisms ensure the proper functioning of the skin.

Midterm Outcomes of Posterior Medial Meniscus Root Tear Repair: A Systematic Review.

Background: Whereas there has been growing interest in surgical repair of posterior medial meniscus root tears (PMMRTs), our understanding of the medium- and long-term results of this procedure is still evolving.

Purpose: To report midterm clinical outcomes from PMMRT repairs.

Study Design: Systematic review.

SARS-CoV-2 in the environment-Non-droplet spreading routes.

The new coronavirus SARS-CoV-2, first identified in Wuhan (China) in December 2019, represents the same family as the Serve Acute Respiratory Syndrome Coronavirus-1 (SARS-CoV-1). These viruses spread mainly via the droplet route. However, during the pandemic of COVID-19 other reservoirs, i.

Stretch too far: rectus sheath haematoma secondary to repetitive trauma and increased intra-abdominal pressure.

A 26-year-old man presented with a 4-week history of right lower quadrant abdominal pain which was managed conservatively at home with ibuprofen. Three days later, he presented to the emergency department with worsening pain and swelling following an episode of coughing and slipping in the bathroom. Following his admission, CT angiography showed an active bleed into a 4.

Determining Efficacy of Intervention in the Limitation of Opioid and Benzodiazepine Co-Prescription.

Introduction: Multiplying the effects of central nervous system and respiratory depression, benzodiazepines are involved in 30 percent of opioid overdoses. The mortality rate in co-administration of both medications is 10 times higher than those taking only opioids. The medication labels even contain direct instructions or "black box" labels warning against their use in conjunction.

Miller Fisher Syndrome Presenting to a Rural South Dakota Hospital.

This report describes a rare case of an 87-year-old woman presenting to a rural emergency department with ataxia. Throughout her admission, she developed areflexia and ophthalmoplegia consistent with a diagnosis of Miller Fisher syndrome. The patient underwent a rapid recovery after receiving treatment with intravenous immunoglobulin (IVIg) for a duration of five days and a two-month period of outpatient physical therapy.

Cushing's Syndrome in a Pregnant Patient Secondary to Adrenal Adenoma: Treatment With Unilateral Adrenalectomy.

Background: A pregnant woman presented with Cushing's syndrome (CS) secondary to adrenal adenoma and was treated with laparoscopic-assisted right adrenalectomy during the second trimester of pregnancy.

Summary: Our patient is a 33-year-old woman who presented with hypertension and cushingoid appearance at 21 weeks gestational age. Laboratory evidence indicated CS was likely, and imaging found a 2.

A Distal Radius Nonunion Treated with A Dorsal Spanning Distraction Plate: A Case Report.

Distal radius fractures are one of the most common orthopedic injuries, particularly in the elderly population. Distal radius nonunions are rare and are usually associated with a patient's underlying health conditions. We present a patient who developed a distal radius nonunion following treatment of an open wrist fracture with an external fixation frame.

Pneumatosis Cystoides Intestinalis Identified on Screening Colonoscopy With Associated Pneumoperitoneum.

Pneumatosis cystoides intestinalis (PCI) is defined by the presence of gas within the bowel wall. It is often asymptomatic and usually benign but may be associated with significant morbidity and mortality. In this patient, PCI was found incidentally on screening colonoscopy, and biopsy of the affected mucosa resulted in deflation of a cyst.

Phase masks for electron microscopy fabricated by thermal scanning probe lithography.

Nano-structured phase masks offer intriguing possibilities in electron-beam shaping. The fabrication of such phase masks is typically achieved by focused (Ga-)ion beam milling of thin membranes. To overcome the problem of Ga implantation in the phase mask, we explore the fabrication of silicon-nitride phase masks using thermal scanning probe lithography combined with wet and dry etching.

3DRA Reconstruction of Intracranial Aneurysms - How does Voxel Size Influences Morphologic and Hemodynamic Parameters.

Three-dimensional shape analysis and imagebased hemodynamic simulations are widely used to assess the individual rupture risk of intracranial aneurysms. However, the quality of those results highly depends on pre-simulative working steps including image reconstruction and segmentation. Within this study, three patient-specific aneurysms were reconstructed using three different voxel sizes (0.

Correlating the nanostructure of Al-oxide with deposition conditions and dielectric contributions of two-level systems in perspective of superconducting quantum circuits.

This work is concerned with Al/Al-oxide(AlO)/Al-layer systems which are important for Josephson-junction-based superconducting devices such as quantum bits. The device performance is limited by noise, which has been to a large degree assigned to the presence and properties of two-level tunneling systems in the amorphous AlO tunnel barrier. The study is focused on the correlation of the fabrication conditions, nanostructural and nanochemical properties and the occurrence of two-level tunneling systems with particular emphasis on the AlO-layer.

(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.

Current therapies for common types of cancer such as renal cell cancer are often ineffective and unspecific, and novel pharmacological targets and approaches are in high demand. Here we show the unexpected possibility for the rapid and selective killing of renal cancer cells through activation of calcium-permeable nonselective transient receptor potential canonical (TRPC) calcium channels by the sesquiterpene (-)-englerin A. This compound was found to be a highly efficient, fast-acting, potent, selective, and direct stimulator of TRPC4 and TRPC5 channels.