Publications by authors named "Radoslaw Kurzelowski"
Article Synopsis
- - This study investigated the safety and effectiveness of stereotactic arrhythmia radioablation (STAR) for treating ventricular tachycardia (VT) in patients who didn't respond to traditional catheter ablation or had contraindications to it.
- - In a group of 11 patients, the trial monitored for severe adverse events, finding that only one patient experienced a significant treatment-related issue, while the others showed an 84.3% reduction in VT symptoms.
- - While STAR shows promise as a safe treatment option for certain patients, further research is needed to evaluate long-term effects and to compare it with existing treatment methods.
Cardiac stereotactic body radiotherapy is an emerging treatment method for recurrent ventricular tachycardia refractory to invasive treatment methods. The single-fraction delivery of 25 Gy was assumed to produce fibrosis, similar to a post-radiofrequency ablation scar. However, the dynamics of clinical response and recent preclinical findings suggest a possible different mechanism.
View Article and Find Full Text PDFBackground: Stereotactic Arrhythmia Radioablation (STAR) is an emerging treatment modality for patients with sustained ventricular tachycardia (VT) and refractory to treatment with drugs and radiofrequency catheter ablation (RFA). It is believed that up to 12-17% of patients experience recurrence of VT within 1 year of follow-up; thus, novel therapeutic options are needed. The aim of this article is to present initial experience within a novel treatment modality for VT.
View Article and Find Full Text PDFIntroduction: Cell therapy has the potential to improve symptoms and clinical outcomes in refractory angina (RFA). Further analyses are needed to evaluate factors influencing its therapeutic effectiveness.
Aim: Assessment of electromechanical (EM) parameters of the left ventricle (LV) and investigation of correlation between EM parameters of the myocardium and response to CD133+ cell therapy.
Left ventricle, LV wringing wall motion relies on physiological muscle fiber orientation, fibrotic status, and electromechanics (EM). The loss of proper EM activation can lead to rigid-body-type (RBT) LV rotation, which is associated with advanced heart failure (HF) and challenges in resynchronization. To describe the EM coupling and scar tissue burden with respect to rotational patterns observed on the LV in patients with ischemic heart failure with reduced ejection fraction (HFrEF) left bundle branch block (LBBB).
View Article and Find Full Text PDFAims: The aim of this study was to determine the relationship between electrical and mechanical activation in heart failure (HF) patients and whether electromechanical coupling is affected by scar.
Methods And Results: Seventy HF patients referred for cardiac resynchronization therapy or biological therapy underwent endocardial anatomo-electromechanical mapping (AEMM) and delayed-enhancement magnetic resonance (CMR) scans. Area strain and activation times were derived from AEMM data, allowing to correlate mechanical and electrical activation in time and space with unprecedented accuracy.
Introduction: There are no data presenting a serial assessment of vein graft healing after bioresorbable vascular scaffold (BVS) implantation at long-term follow-up.
Aim: To describe ABSORB BVS healing in vein grafts by optical coherence tomography (OCT) and high-definition intravascular imaging (HD-IVUS) at long-term follow-up.Material and methods: The study group consisted of 6 patients.
Article Synopsis
- - The study investigates the relationship between bone metabolism factors and myocardial injury in STEMI patients by analyzing various serum markers and microRNA expressions at two time points: after 4 days and 3 months post-myocardial infarction.
- - A total of 25 STEMI patients were enrolled, and measurements included osteogenesis/osteolysis factors and microRNA levels, with cardiac function assessed through MRI.
- - The findings revealed no significant changes in the levels of these factors or microRNAs over the 3-month period, and there was no correlation with improvements in left ventricular function, although a negative correlation was found between osteoprotegerin levels and left ventricular ejection fraction in the acute phase.