Quantitative SPECT/CT imaging of actinium-225 for targeted alpha therapy of glioblastomas.

Background: A new, alternative option for patients with recurrent glioblastoma is targeted alpha therapy (TAT), in the form of a local administration of substance P (neurokinin type 1 receptor ligand, NK-1) labelled with Ac. The purpose of the study was to confirm the feasibility of quantitative SPECT imaging of Ac, in a model reproducing specific conditions of TAT. In particular, to present the SPECT calibration methodology used, as well as the results of validation measurements and their accuracy.

Locoregional Treatment of Glioblastoma With Targeted α Therapy: [ 213 Bi]Bi-DOTA-Substance P Versus [ 225 Ac]Ac-DOTA-Substance P-Analysis of Influence Parameters.

Background: Glioblastoma (GB) is the most malignant primary brain tumor. Therefore, introduction of new treatment options is critically important. The aim of this study was to assess local treatment with α emitters [ 213 Bi]Bi-DOTA-substance P (SP) and [ 225 Ac]Ac-DOTA-SP.

Dose escalation study of targeted alpha therapy with [Ac]Ac-DOTA-substance P in recurrence glioblastoma - safety and efficacy.

Unlabelled: Glioblastoma is the most common and malignant primary brain tumour, with a poor prognosis. Introduction of new treatment options is critically important. The study aimed to assess the appropriateness of escalation doses and toxicity of [Ac]Ac-DOTA-SP therapy.

68Ga-Prostate-Specific Membrane Antigen-11 PET/CT: A New Imaging Option for Recurrent Glioblastoma Multiforme?

Background: Glioblastoma multiforme (GBM) is the most common and most aggressive primary tumor of the brain. After initial therapy and total resection of GBM, 80% to 90% of recurrences occur at the surgical margins. Currently, limited data are available in the literature on the possible use of Ga-prostate-specific membrane antigen (PSMA-11) for diagnosis of recurrence in GBM patients.

The neural correlates of specific executive dysfunctions in Parkinson's disease.

Several functional neuroimaging studies in patients with Parkinson's disease (PD) have suggested that changes in the fronto-parietal-striatal networks are associated with deficits in executive functioning. However, executive functions (EF) are multifaceted and include three dissociable components: working memory, response inhibition, and task-switching. This study investigated which component of executive functioning is most strongly associated with fronto-parietal-striatal efficiency in PD.

Neuropsychological assessment of language functions during functional magnetic resonance imaging: development of new tasks. Preliminary report.

Background And Purpose: Due to the complex and extended cerebral organization of language functions, the brain regions crucial for speech and language, i.e. eloquent areas, have to be affected by neurooncological surgery.