GJB2 mutations in Mongolia: complex alleles, low frequency, and reduced fitness of the deaf.

We screened the GJB2 gene for mutations in 534 (108 multiplex and 426 simplex) probands with non-syndromic sensorineural deafness, who were ascertained through the only residential school for the deaf in Mongolia, and in 217 hearing controls. Twenty different alleles, including four novel changes, were identified. Biallelic GJB2 mutations were found in 4.

Efficacy of two intervals and two routes of administration of misoprostol for termination of early pregnancy: a randomised controlled equivalence trial.

Background: The most effective route and best interval between several doses of misoprostol to induce abortion have not been defined. Our aim was to assess the effects of the interval between multiple doses of misoprostol and the route of administration to terminate pregnancy.

Methods: 2066 healthy pregnant women requesting medical abortion with 63 days or less of gestation were randomly assigned within 11 gynaecological centres in six countries to the four treatment groups (three doses of 0.

WHO multinational study of three misoprostol regimens after mifepristone for early medical abortion.

Objectives: To compare the side effect profiles of regimens of oral and vaginal administration of misoprostol after a single oral dose of 200 mg of mifepristone and to investigate patients' perceptions of medical abortion.

Design: Double-blind, randomised controlled trial.

Setting: Fifteen gynaecological clinics in 11 countries.

WHO multinational study of three misoprostol regimens after mifepristone for early medical abortion. I: Efficacy.

Objectives: To compare the efficacy of oral and vaginal administration of misoprostol after a single oral dose of 200 mg of mifepristone and to investigate whether the efficacy can be improved and the duration of bleeding shortened by continuing oral misoprostol for one week.

Design: Double blind, randomised controlled trial.

Setting: Fifteen gynaecological clinics in 11 countries.