Publications by authors named "Radik S Faskhutdinov"
Cancer Drug Resist
November 2024
Article Synopsis
- Resistance to hormonal and targeted therapies in breast cancer is influenced by epigenetic alterations, particularly through DNA methylation changes linked to DNMT3A suppression.
- The study investigates the role of NR6A1 as a regulatory factor involved in this suppression, finding that its downregulation is critical for developing resistance.
- The research reveals that changes in cell signaling pathways and the activation of Snail, a key regulator, are associated with resistance, suggesting that the NR6A1/DNMT3A axis could help inform future breast cancer treatment strategies.
