Publications by authors named "Radi F Zaki"
Multimodal pain management strategies including pregabalin (PGB) have been shown to reduce pain and opioid use after many types of surgeries. This was a single-center, retrospective study aimed to determine whether a single pre-operative dose of PGB reduces opioid requirements and post-operative pain after orthotopic liver transplantation (OLT). Outcomes included the mean morphine milligram equivalents used; the proportion of patients with no pain documented; and the maximum level of pain documented within the first 24h and in the 24-72h following OLT.
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- Thrombotic microangiopathy is a condition characterized by endothelial damage and microangiopathic hemolytic anemia, often occurring after kidney transplants.
- Certain immunosuppressive drugs, particularly calcineurin inhibitors and mTOR inhibitors, are commonly linked to triggering this condition, alongside acute antibody-mediated rejection and infections.
- A case series of 3 patients who developed de novo thrombotic microangiopathy post-kidney transplant—prior to starting calcineurin inhibitors—revealed that two patients successfully managed their condition with plasma exchange and later tolerated calcineurin inhibitors without recurrence.
Objectives: This paper sought to determine if there were an association between drain placement and the incidence of wound complications.
Materials And Methods: A single-center institutional review board-approved retrospective study between 2001 to 2008, comparing 680 kidney transplant patients who either had a drain placed or were left undrained. Linear regression modeling was used to adjust the risk factors between the groups.
Article Synopsis
- The study investigates the use of thymoglobulin in elderly kidney transplant recipients (≥ 65 years) compared to younger recipients, focusing on short-term effectiveness and safety.
- Elderly recipients were found to receive lower doses of thymoglobulin and mycophenolic acid, and they experienced less delayed graft function, yet had lower 3-year patient survival rates despite similar graft survival and function metrics.
- Overall, while elderly patients showed fewer immediate complications, the long-term outlook in terms of patient survival was worse, primarily linked to donor age.
The worldwide focus on work hour regulations and patient safety has led to the re-examination of the merits of night-time surgery, including kidney transplantation. The risks of operating during nontraditional work hours with potentially fatigued surgeons and staff must be weighed against the negative effects of prolonged cold ischemic time with resultant graft compromise. The aim of this study was to evaluate the impact of performing renal transplantation procedures during evening versus day time hours.
View Article and Find Full Text PDFIt is well established that ischemic times affect rates of delayed graft function (DGF) and allograft survival following deceased donor kidney transplant. There is, however, a paucity of data regarding what we term extraction time, the time between aortic cross-clamp and perfusion/cooling, and removal of the kidneys from the body and placement on ice on the back table. We posit that this time is an additional insult, and may significantly contribute to transplant kidney function.
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