Altered morphokinetics and differential reproductive outcomes associated with cell exclusion events in human embryos.

Research Question: Can embryos harbouring cell exclusion and their reproductive outcomes be classified based on morphokinetic profiles?

Design: A total of 469 time-lapse videos of embryos transferred between 2013 and 2019 from a single clinic were analysed. Videos were assessed and grouped according to the presence or absence of one or more excluded cells before compaction. Cell division timings, intervals between subsequent cell divisions and dynamic intervals were analysed to determine the morphokinetic profiles of embryos with cell exclusion (CE+), compared with fully compacted embryos without cell exclusion or extrusion (CE-).