Publications by authors named "Radhey Shyam Sharma"

Article Synopsis
  • Understanding how bacteriophages and bacteria interact in different environments is crucial for improving ecological restoration efforts, particularly in areas like abandoned mines.
  • The study focuses on Pseudomonas bacterial communities and their interactions with phages in various soil microhabitats, using techniques like X-ray analysis and DNA sequencing to investigate these relationships.
  • Results showed that while bacterial communities are similar across microhabitats, their responses to phages vary significantly, with certain minerals influencing phage infectivity and bacterial resistance, which is important for enhancing microbial applications in ecosystem restoration.
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Article Synopsis
  • * In natural ecosystems, microbial communities showed the ability to decolorize AO7, with shifts in community composition where nitrogen-fixing Niveispirillum decreased significantly, potentially affecting nutrient balance, while Pseudomonas sp. increased, indicating resilience to pollutants.
  • * Functional profiling revealed that AO7 exposure led to reduced protein metabolism and nutrient availability, increased oxidative stress, and disturbing methane metabolism, which could contribute to global warming and further harm aquatic ecosystems.
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Unchecked dye effluent discharge poses escalating environmental and economic concerns, especially in developing nations. While dyes are well-recognized water pollutants, the mechanisms of their environmental spread are least understood. Therefore, the present study examines the partitioning of Acid Orange 7 (AO7) and Crystal Violet (CV) dyes using water-sediment microcosms and reports that native microbes significantly affect AO7 decolorization and transfer.

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The unregulated use of organochlorine pesticides (OCPs) has been linked to spread of breast cancer (BC), but the underlying biomolecular interactions are unknown. Using a case-control study, we compared OCP blood levels and protein signatures among BC patients. Five pesticides were found in significantly higher concentrations in breast cancer patients than in healthy controls: p',p' dichloro diphenyl trichloroethane (DDT), p'p' dichloro diphenyl dichloroethane (DDD), endosulfan II, delta-hexachlorocyclohexane (dHCH), and heptachlor epoxide A (HTEA).

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  • Hypertensive disorders of pregnancy (HDP) affect 5%-10% of pregnancies globally, with four main types identified, including preeclampsia (PE), which significantly contributes to maternal and fetal deaths worldwide.
  • Preeclampsia is a complex disorder usually diagnosed after 20 weeks of pregnancy and is linked to issues in the immune system and inadequate blood flow to the placenta, causing various complications.
  • Current research suggests that targeting the immune system with specific medications could provide new treatment options for preeclampsia, as the immune dysfunction plays a key role in its development.
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Phototrophic communities of autotrophic microalgae and heterotrophic bacteria perform complex tasks of nutrient acquisition and tackling environmental stress but remain underexplored as a basis for the bioremediation of emerging pollutants. In industrial monoculture designs, poor iron uptake by microalgae limits their productivity and biotechnological efficacy. Iron supplementation is expensive and ineffective because iron remains insoluble in an aqueous medium and is biologically unavailable.

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Antibiotics as a selection pressure driving the evolution of soil microbial communities is not well understood. Since microbial functions govern ecosystem services, an ecological framework is required to understand and predict antibiotic-induced functional and structural changes in microbial communities. Therefore, metagenomic studies explaining the impacts of antibiotics on soil microbial communities were mined, and alterations in microbial taxa were analyzed through an ecological lens using Grimes's Competitor-Stress tolerator-Ruderal (CSR) model.

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Growing evidence recommends that radiofrequency radiations might be a new type of environmental pollutant. The consequences of RFR on the human immune system have gained considerable interest in recent years, not only to examine probable negative effects on health but also to understand if RFR can modulate the immune response positively. Although several studies have been published on the immune effects of RFR but no satisfactory agreement has been reached.

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  • Microplastics (MPs) are widespread in pristine environments and present significant risks due to their non-biodegradable nature and ability to bind with other contaminants, posing threats to ecosystems and human health.
  • Their small size, varied surface properties, and resilience against environmental conditions make them difficult to mitigate, leading to complex interactions with other pollutants that can alter toxicity levels.
  • A review of 171 studies highlights the need for more targeted research to address knowledge gaps and better understand the environmental impacts of MPs, considering the disproportionate risks faced by different regions.
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A sectorial approach for assessing heavy metal pollution in rivers neglects the inter-relationship between its environmental compartments and thus fails to report realistic pollution status and associated ecological and human health risks. Therefore, a systems approach was adopted to assess heavy metal pollution and associated risks in the Yamuna River (Delhi, India), one of the world's most polluted and populated river-city pairs. Sampling sites selected along the river with distinct land use were uncultivated natural floodplain vegetation, marshy area, invasive community, arable land, and human settlements.

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Microbial fuel cells (MFCs) exhibit tremendous potential in the sustainable management of dye wastewater via degrading azo dyes while generating electricity. The past decade has witnessed advances in MFC configurations and materials; however, comprehensive analyses of design and material and its association with dye degradation and electricity generation are required for their industrial application. MFC models with high efficiency of dye decolorization (96-100%) and a wide variation in power generation (29.

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With increasing technological developments, exposure to non-ionizing radiations has become unavoidable as people cannot escape from electromagnetic field sources, such as Wi-Fi, electric wires, microwave oven, radio, telecommunication, bluetooth devices, etc. These radiations can be associated with increased health problems of the users. This review aims to determine the effects of non-ionizing electromagnetic radiations on female fertility.

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Per-/poly-fluoroalkyl substances (PFAS) are an emerging class of environmental contaminants used as an additive across various commodity and fire-retardant products, for their unique thermo-chemical stability, and to alter their surface properties towards selective liquid repellence. These properties also make PFAS highly persistent and mobile across various environmental compartments, leading to bioaccumulation, and causing acute ecotoxicity at all trophic levels particularly to human populations, thus increasing the need for monitoring at their repositories or usage sites. In this review, current nano-enabled methods towards PFAS sensing and its monitoring in wastewater are critically discussed and benchmarked against conventional detection methods.

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Background: There is scanty data in India on polycystic ovary syndrome (PCOS) from several small, undersized, convenience-based studies employing differing diagnostic criteria and reporting varied regional prevalence. It is difficult to draw clear-cut conclusions from these studies; therefore, the present multicentric, well-designed, large-scale representative countrywide epidemiological study on PCOS across India was conceived with the aim to generate the actual prevalence rates of PCOS in India with a total sample size of approximately 9000 individuals.

Objective: The primary objectives of the study are to estimate the national prevalence of PCOS in India and the burden of comorbidities and to compare the variation in efficacy of standard therapeutic modalities for metabolic dysfunction in women with PCOS.

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Background: Progress has been made in the reduction of under-five mortality in India; however, neonatal mortality is reducing at a slower rate. Efforts are required to bring down neonatal mortality in order to attain the Sustainable Development Goal-3. Prevention of sepsis among the high-risk, vulnerable low birth weight neonates by a newer intervention with probiotic supplementation is promising.

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In recent years, nanotechnology has revolutionized global healthcare and has been predicted to exert a remarkable effect on clinical medicine. In this context, the clinical use of nanomaterials for cancer diagnosis, fertility preservation, and the management of infertility and other pathologies linked to pubertal development, menopause, sexually transmitted infections, and HIV (human immunodeficiency virus) has substantial promise to fill the existing lacunae in reproductive healthcare. Of late, a number of clinical trials involving the use of nanoparticles for the early detection of reproductive tract infections and cancers, targeted drug delivery, and cellular therapeutics have been conducted.

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Nanopriming is an emerging field of science which uses nanoparticles in solution to improve parameters of seed vigor. This leads to an initial advantage to the crop plant at the germination phase of its life cycle, which is also the most vulnerable phase and may lead to an improved yield. In this study, we have synthesized copper oxide (CuO) and (3-Aminopropyl) triethoxysilane (APTES)-coated CuO (CuO@APTES) nanoparticles via environmentally friendly green synthesis using the extract of Coriandrum sativum (coriander) herb.

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Implantation in humans is a multistep process that involves apposition, adhesion, and invasion of the developing blastocyst into the receptive maternal endometrium. Though significant volume of research in this direction has identified important players orchestrating this delicate process, there are still gaps in our understanding of all the sequence of events during embryo implantation. Also, the early pregnancy-related complications that lead to fetal loss and miscarriage often occur in this critical window of implantation, which is primarily defined as the time when the maternal endometrium is supposed to be most receptive to the free blastocyst that emerges out from the zona pellucida.

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The advent of wireless technologies has revolutionized the way we communicate. The steady upsurge in the use of mobile phone all over the world in the last two decades, while triggered economic growth, has caused substantial damage to the environment, both directly and indirectly. The electromagnetic radiation generated from mobile phones, radio-based stations, and phone towers, high-voltage power lines have been reported which leads to the variety of health scares such as the risk of cancer in human beings and adverse effects in animals, birds, etc.

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The practice of hair dyeing is a rapidly expanding industry on a global scale; however, it has become a major concern for Asian countries because they have been undergoing rapid transformations of their environment and lifestyles. While the socio-economic benefits and impacts of this globalization trend are widely understood, the environmental effects are largely unknown. In particular, commonly available oxidative dyes potentially pose specific environmental risks due to their use of a toxic aromatic amine p-Phenylenediamine (PPD).

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Phenolics drive the global economy, but they also pose threats to soil health and plant growth. Enzymes like peroxidase have the potential to remove the phenolic contaminants from the wastewater; however, their role in restoring soil health and improving plant growth has not yet been ascertained. We fractionated efficient peroxidases (MPx) from leaves of an invasive species of Mesquite, Prosopis juliflora, and demonstrated its superiority over horseradish peroxidase (HRP) in remediating phenol, 3-chlorophenol (3-CP), and a mixture of chlorophenols (CP-M), from contaminated soil.

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Objectives: This study examined the effects of plasma-rich growth factors (PRGF) on accelerating bone regeneration/repair in fresh extraction sockets, and determined the quality and quantity of bone by assessing the bone density using cone-beam computed tomography (CBCT).

Materials And Methods: Twenty patients, who had undergone bilateral extractions, were included in this study. In one extraction socket, PRGF was used and covered with an autologous fibrin plug.

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One of the most promising applications of nanomaterials is that of nanobiosensors, using biomolecules such as nucleic acids as receptors. This study aimed to synthesize nickel oxide nanoparticles (NiO NPs) by an environmentally friendly green synthesis, using the extract of the herb Coriandrum sativum (coriander). The synthesized NPs were characterized using UV-Visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, X-ray photon spectroscopy, field emission scanning electron microscopy coupled with energy dispersive spectroscopy, dynamic light scattering, zeta potential and transmission electron microscopy.

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Background & Objectives: For improved male contraception, a new polymeric drug molecule - Reversible Inhibition of Sperm under Guidance (RISUG) has been synthesized and has been found to be effective, safe and reversible in various animal species. Phase-I and phase-II clinical trials have confirmed its safety and contraceptive efficacy. The present study was undertaken as a multicentric-limited phase-III clinical trial to test the efficacy and safety of RISUG in human volunteers.

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