The arginine/ornithine binding protein ArgT plays an essential role in / to prevent intracellular killing and contribute to chronic persistence in the host.

species are facultative intracellular bacterial pathogens that cause the contagious zoonotic disease, brucellosis. spp. infect a wide range of animals, including livestock, wild animals, and marine mammals.

Heteroepitaxial GaAs thin-films on flexible, large-area, single-crystal-like substrates for wide-ranging optoelectronic applications.

Recent advances in semiconductor based electronic devices can be attributed to the technological demands of ever increasing, application specific markets. These rapidly evolving markets for devices such as displays, wireless communication, photovoltaics, medical devices, etc. are demanding electronic devices that are increasingly thinner, smaller, lighter and flexible.

A man having 'cyst' in the 'cyst'!

Hydatid disease is a zoonotic parasitic infestation caused by tapeworms, particularly . The lung is the second most site followed by liver accounting for 10%-30% of the cases. Rupture of hydatid cyst can occur into pleura or bronchus.

targets the host ubiquitin-specific protease, , through the effector protein, TcpB, for facilitating infection of macrophages.

species are Gram-negative intracellular bacterial pathogens that cause the worldwide zoonotic disease brucellosis. can infect many mammals, including humans and domestic and wild animals. manipulates various host cellular processes to invade and multiply in professional and non-professional phagocytic cells.

Immuno-profiling of proteins for developing improved vaccines and DIVA capable serodiagnostic assays for brucellosis.

Brucellosis remains a worldwide zoonotic disease with a serious impact on public health and livestock productivity. Controlling brucellosis in livestock is crucial for limiting human infections in the absence of effective human vaccines. Brucellosis control measures are majorly dependent on rigorous monitoring of disease outbreaks and mass vaccination of livestock.

Influence of Aspect Ratio on the Flexural and Buckling Behavior of an Aluminium Sandwich Composite: A Numerical and Experimental Approach.

In the field of engineering materials, lightweight and ultra-lightweight composites are used in real time to a greater extent, with high-performance targeting for tailor-made systems in aerospace, automotive, and biomedical applications. Sandwich composites are among the most popular lightweight materials used in structural and vehicle-building applications. In the present investigation, one such sandwich composite laminate composed of aluminum face sheets and a high-density polyethylene core was considered to analyze sandwich composites' flexural and buckling behavior experimentally and numerically.

Outer membrane protein 25 of Brucella suppresses TLR-mediated expression of proinflammatory cytokines through degradation of TLRs and adaptor proteins.

Toll-like receptors (TLRs) are essential components of innate immunity that serves as the first line of defense against the invaded microorganisms. However, successful infectious pathogens subvert TLR signaling to suppress the activation of innate and adaptive responses. Brucella species are infectious intracellular bacterial pathogens causing the worldwide zoonotic disease, brucellosis, that impacts economic growth of many countries.

Experimental and Numerical Study on the Influence of Stress Concentration on the Flexural Stability of an Aluminium Hollow Tube.

In recent times, particularly in applications used to build various structures for construction purposes or machines, solid sections have been gradually replaced by hollow sections due to their attractive features such as being light weight and having high specific strength. In the present investigation, an attempt was made to investigate, in detail, the flexural capability of aluminium hollow tubes (AHTs) with square cross-sections. The objective of the investigation was to study the influence of stress concentration on the flexural behaviour of the hollow tube.

Single-crystal-like germanium thin films on large-area, compliant, light-weight, flexible, single-crystal-like substrates.

Germanium (Ge) films were heteroepitaxially grown on flexible, large-area, single-crystal-like metallic substrates. Multiple, heteroepitaxial, buffer layers of nanoscale dimensions were deposited on the triaxially textured, single-crystal-like, thermo-mechanically processed Ni-W alloy substrates. Ge films were deposited on a CeO-terminated, heteroepitaxial buffer stack on the metallic substrate using electron beam evaporation.

PARP1 Inhibition and Effect on Burn Injury-Induced Inflammatory Response and Cardiac Function.

Background: Burn injury induces multiple signaling pathways leading to a significant inflammatory storm that adversely affects multiple organs, including the heart. Poly (ADP-ribose) polymerase inhibitor 1 (PARP1) inhibition, with specific agents such as N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide (PJ34), is effective in reducing oxidative stress and cytokine expression in the heart. We hypothesized that PARP1 inhibition would reduce inflammatory signaling and protect against burn injury-induced cardiac dysfunction.

Assessing amino acid solubility of black soldier fly larvae meal in Atlantic salmon () and .

and methods were used to evaluate amino acids solubility of black soldier fly (BSF) larvae meal and two experimental diets (reference and test diets) for Atlantic salmon. The current study used method such as pH stat to compare and standardise the salmon extracted enzyme (SE), and commercial enzyme (CE) based on their hydrolytic capacity on a purified protein substrate. Further, an amino acid solubility of feed ingredients and diets were measured using the standardised enzyme volume from SE and CE.

A meta-analysis assessing time for return to sport following hip resurfacing.

Background: Hip resurfacing arthroplasty (HRA) is associated with excellent functional outcomes and return to pre-disease level of activity. The time for return to sport (RTS) following HRA remains unknown. The aim of this meta-analysis was to establish the time for RTS following HRA.

Regulation of Key Immune-Related Genes in the Heart Following Burn Injury.

Immune cascade is one of major factors leading to cardiac dysfunction after burn injury. TLRs are a class of pattern-recognition receptors (PRRs) that initiate the innate immune response by sensing conserved molecular patterns for early immune recognition of a pathogen. The Rat Toll-Like Receptor (TLR) Signaling Pathway RT² Profiler PCR Array profiles the expression of 84 genes central to TLR-mediated signal transduction and innate immunity, and is a validated tool for identifying differentially expressed genes (DEGs).

Host F-Box Protein 22 Enhances the Uptake of Brucella by Macrophages and Drives a Sustained Release of Proinflammatory Cytokines through Degradation of the Anti-Inflammatory Effector Proteins of Brucella.

Brucella species are intracellular bacterial pathogens, causing the worldwide zoonotic disease brucellosis. Brucella invades professional and nonprofessional phagocytic cells, followed by resisting intracellular killing and establishing a replication permissive niche. Brucella also modulates the innate and adaptive immune responses of the host for its chronic persistence.

Return to Sport After Unicompartmental Knee Arthroplasty: A Systematic Review and Meta-analysis.

Background: Patients undergoing unicompartmental knee arthroplasty (UKA) often want to return to sport (RTS) after surgery. However, the time taken to RTS and proportion of patients who RTS after UKA remain unknown.

Purpose: To determine the time to RTS and proportion of patients who RTS after UKA.

Nuclear Factor Erythroid 2-Related Factor 2 Activation and Burn-Induced Cardiac Dysfunction.

Background: Our previous studies have found that burn injury induces cardiac dysfunction through interruption of the antioxidant-response element (ARE) pathway in cardiac mitochondria. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator that activates many antioxidant enzymes. Oltipraz (Olti) is a Nrf2 activator and a well-known inducer of NQO1 along with other enzymes that comprise the Nrf2-associated antioxidants.

Caveats of Local Fasciocutaneous Flaps for Distal Leg Defects-Anatomical Study and Clinical Application.

The present trend for the management of distal leg defects is to opt for a free flap with local flaps being relegated to the backseat. We studied the perforator anatomy of the distal leg in the Indian population to see if there were any ethnic differences and then correlated it with a clinical study of local flaps used for the coverage of distal leg defects. A prospective observational study was carried out in 2 phases-anatomical study and clinical study from December 2018 to March 2020.

Time for return to sport following total knee arthroplasty: a meta-analysis.

Introduction: The frequency of total knee arthroplasty (TKA) is increasing, particularly in younger and more active patients. In these patients, there may be greater functional demands, with an expectation to return to sporting activities (RTS) following TKA. There is a paucity of data on the time to RTS following TKA and the aim of this meta-analysis is to determine the time to RTS following TKA.

Time for return to sport following total hip arthroplasty: a meta-analysis.

Introduction: Total Hip Arthroplasty (THA) is being increasingly undertaken in younger and more active patients, with many of these patients wanting to return to sport (RTS) after surgery. However, the percentage of patients RTS and time at which they are able to get back to sport following surgery remains unknown. The objective of this meta-analysis was to determine the time patients RTS after THA.

Nursing considerations for patients undergoing robotic-arm assisted joint replacements.

Robotic-arm assisted arthroplasty (RAA) has gained popularity over the past decade because of its ability to provide more accurate implant positioning with less surgical trauma than conventional manual arthroplasty. It has shown better early functional outcomes, less postoperative pain and shorter inpatient stays. A multidisciplinary approach is crucial in improving overall outcomes and ensuring this technology is implemented efficiently and safely, but there is limited published literature on the nursing considerations for managing patients undergoing RAA.

Lipid exchanges drove the evolution of mutualism during plant terrestrialization.

Symbiosis with arbuscular mycorrhizal fungi (AMF) improves plant nutrition in most land plants, and its contribution to the colonization of land by plants has been hypothesized. Here, we identify a conserved transcriptomic response to AMF among land plants, including the activation of lipid metabolism. Using gain of function, we show the transfer of lipids from the liverwort to AMF and its direct regulation by the transcription factor WRINKLED (WRI).

Linn leaves ameliorates experimental induced heart failure in Wistar rats.

Objectives: Cardiovascular diseases (CVDs) are highly prevalent in various countries, and heart failure accounts for the majority of deaths. The present study focuses on determining the protective effect of ethanol extract of leaves of (TIEE) by and methods.

Methods: cardiotonic activity was determined using Langendorff's heart perfusion assembly.

Cementless knee arthroplasty: a review of recent performance.

Cementless knee arthroplasty has seen a recent resurgence in popularity due to conceptual advantages, including improved osseointegration providing biological fixation, increased surgical efficiency, and reduced systemic complications associated with cement impaction and wear from cement debris. Increasingly younger and higher demand patients are requiring knee arthroplasty, and as such, there is optimism cementless fixation may improve implant survivorship and functional outcomes. Compared to cemented implants, the National Joint Registry (NJR) currently reports higher revision rates in cementless total knee arthroplasty (TKA), but lower in unicompartmental knee arthroplasty (UKA).

Effect of Mitochondrial Antioxidant (Mito-TEMPO) on Burn-Induced Cardiac Dysfunction.

Background: Imbalance of oxidants/antioxidants results in heart failure, contributing to mortality after burn injury. Cardiac mitochondria are a prime source of reactive oxygen species (ROS), and a mitochondrial-specific antioxidant may improve burn-induced cardiomyopathy. We hypothesize that the mitochondrial-specific antioxidant, Triphenylphosphonium chloride (Mito-TEMPO), could protect cardiac function after burn.

Evaluation of maternal plasma platelet activating factor acetylhydrolase activity and mRNA expression in pre-eclampsia: a case control study.

Preeclampsia (PE) remains a leading cause of maternal morbidity and mortality all over the world. However, its aetiology and pathophysiology remain elusive. Platelet activating factor (PAF) is produced in response to oxidative stress and is a potent hypotensive agent.