Publications by authors named "Radhakishan Narsini"
Background and objectives Endothelial soluble lectin-type oxidized low-density lipoprotein receptor 1 (sLOX-1) recognizes oxidized low-density lipoprotein (LDL) and triggers downstream signaling leading to atherosclerosis. The objective of this study was to demonstrate the utility of sLOX-1 as a biomarker for detecting acute myocardial infarction (MI) and stable angina (SA) and to develop a diagnostic algorithm for distinguishing coronary vasospasm from coronary plaque rupture. Methods We enrolled 62 patients who underwent diagnostic coronary angiography (CAG) and 30 healthy controls (21 men and nine women) and measured sLOX-1, troponin I, and cardiac myosin-binding protein C (c-MyBPC) using commercial kits.
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- Researchers developed novel copper(II) compounds as fluorogenic probes specifically to detect homocysteine, a key cardiac biomarker, without interference from other substances in blood plasma like cysteine and glutathione.
- The probes exhibited a significant enhancement in fluorescence (up to 111 times) upon interacting with homocysteine, confirmed through UV-vis and EPR studies demonstrating their "off-to-on" detection capability.
- Clinical tests showed that these probes could reliably measure homocysteine levels in human plasma, offering a new and specific method for cardiac sample analysis compared to traditional immunoassay kits.