Dengue Burden and Circulation of Dengue-2 Serotype Among Children Along With Clinical Profiling in Uttarakhand, India: A Cross-Sectional Study From 2018 to 2020.

Background: The multiple serotypes of the dengue virus (DENV) are always a major public concern for dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS).

Objective: This study aimed to analyse the demographic characteristics and circulating serotypes of dengue among the paediatric age group.

Methodology: One hundred forty-one clinically suspected children were enrolled in the study from 2018 to 2020 in a tertiary care hospital in Uttarakhand, India.

An insight into clinical and laboratory detections for screening and diagnosis of cervical cancer.

Introduction: Cervical cancer is the most frequent malignancy among women caused by an unresolved long-term infection with distinct human papillomavirus (HPV) genotypes. It is the fourth most common form of cancer among women worldwide. The two oncogenic genotypes, HPV 16 and 18, are responsible for >70% of all cervical cancers worldwide.

Th1 immune response takeover among patients with severe Japanese encephalitis infection.

The present study was intended to explore the dynamics of viral and host factors determining the outcome of Japanese encephalitis viral infection. 223 patients with acute encephalitic syndrome, 126 with febrile illness suspected of JE and 79 apparently healthy individuals as control were enrolled. Elevated levels of TNF-α and IL-6 in encephalitis patients and IFN-γ in febrile JE patients without encephalitis were observed.

High levels of circulating HMGB1 as a biomarker of acute liver failure in patients with viral hepatitis E.

Background: Viral hepatitis E clinically ranges between acute self-limiting hepatitis (AVH) and acute liver failure (ALF). The varied clinical course of the disease possibly thought to be immune-mediated. High-mobility group box 1 (HMGB1) is a non-histone chromosomal nuclear protein with recently discovered pro-inflammatory and immunomodulatory action.

Usefulness of reverse transcriptase-polymerase chain reaction for detection of rabies RNA in archival samples.

The examination of archival samples by molecular techniques has been found to be a valuable tool in providing retrospective and epidemiological data. In contrast to DNA, there are fewer comprehensive studies quantitatively addressing the feasibility of assessing RNA from archival samples. In tropical countries like India, such studies are even more rare.