Publications by authors named "Racquel Oliveira da Silva Souza"
Dioclea violacea lectin has potent in vitro leishmanicidal activity against Leishmania infantum via carbohydrate recognition domain.
Int J Biol Macromol
September 2024
Article Synopsis
- Existing leishmaniasis treatments have limitations and side effects, prompting the exploration of new alternatives like the lectin DVL from Dioclea violacea seeds.
- DVL showed significant leishmanicidal effects against Leishmania infantum in vitro, inducing reactive oxygen species and damaging the parasite's membrane, with an effective concentration of 49.37 μg/mL.
- DVL enhanced the effectiveness of traditional drugs like amphotericin B and glucantime, reduced macrophage infection rates, and exhibited no toxicity in healthy cells, indicating its potential as a treatment for visceral leishmaniasis.
Structural characterization of a galectin isolated from the marine sponge Chondrilla caribensis with leishmanicidal potential.
Biochim Biophys Acta Gen Subj
December 2021
Article Synopsis
- * Molecular docking analysis indicated that CCL interacts with carbohydrates in a way similar to other galectins, and it demonstrated significant anti-leishmanial activity by inhibiting the growth of the Leishmania infantum parasite.
- * CCL is recognized as one of the few sponge lectins with a fully determined primary structure, showing great potential for biotechnological applications, particularly in the fight against diseases like Leishmaniasis.
Leishmaniases are a complex of sand fly-borne diseases that are considered a public health issue in several countries. Brazil presents high leishmaniases rates. The South of Ceará State, known as Cariri region, shows worrying statistics mainly on American tegumentary leishmaniasis.
View Article and Find Full Text PDFEthnopharmacological Relevance: The parts of the Genipa americana (Rubiaceae) tree, also known as "jenipapo" or "jenipapeiro", has been used in traditional Medicine in parasitic and bacterial infections. Thus, the experimental evolution of the antiparasitic activity of polysaccharide extracts from Genipa americana leaves, and correlation with antiparasitic and popular use is important.
Aim Of The Study: To evaluate the effect of polysaccharide extract obtained from Genipa americana leaves on all Trypanosoma cruzi (Y strain: benznidazole-resistant) developmental forms, a protozoan that causes Chagas' disease.
Chagas' disease is a neglected disease caused by the protozoan parasite Trypanosoma cruzi and constitutes a serious health problem worldwide. The treatment is limited, with variable efficacy of benznidazole and nifurtimox. Betulinic Acid (BA), a triterpene, can be found in medicinal herbs and has a wide variety of biological and pharmacological activities.
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