Fluorescence by self-assembly: autofluorescent peptide vesicles and fibers.

A series of oxidized cysteinyl peptides ([P-Cys-X-OMe]; P = Boc or H; X = Trp or Glu) showed vesicular and fibrillar assemblies. The anatomy of the self-assembled vesicles from the water-soluble cystine peptide [Cys-Trp-OMe] (1a) has been investigated by using various fluorescent probes such as ammonium 8-anilinonaphthalene-1-sulfonate, Nile Red and pyrene. The morphological characterization was carried out by fluorescence lifetime imaging microscopy (FLIM) and super resolution-structured illumination microscopy (SR-SIM) utilizing the autofluorescence of the vesicles stemming from the self-assembly.

Interaction of borohydride stabilized silver nanoparticles with sulfur-containing organophosphates.

Understanding the interactions between nanoparticles and organophosphates is the key to developing cost-effective colorimetric pesticide detection. We have studied the interaction between three different organophosphates containing the P[double bond, length as m-dash]S group and borohydride stabilized silver nanoparticles. Three different organophosphates, namely phorate, chlorpyrifos, and malathion, have been used.

Chemical Biology of Sortase A Inhibition: A Gateway to Anti-infective Therapeutic Agents.

is the leading cause of hospital-acquired infections. The enzyme sortase A, present on the cell surface of , plays a key role in bacterial virulence without affecting the bacterial viability. Inhibition of sortase A activity offers a powerful but clinically less explored therapeutic strategy, as it offers the possibility of not inducing any selective pressure on the bacteria to evolve drug-resistant strains.

Designer Peptide and Protein Dendrimers: A Cross-Sectional Analysis.

Dendrimers have attracted immense interest in science and technology due to their unique chemical structure that offers a myriad of opportunities for researchers. Dendritic design allows us to present peptides in a branched three-dimensional fashion that eventually leads to a globular shape, thus mimicking globular proteins. Peptide dendrimers, unlike other classes of dendrimers, have immense applications in biomedical research due to their biological origin.