Descriptive analysis of molecular subtypes in Tunisian breast cancer.

Aim: The objective is to report the correlation between pathology and molecular subtype classifications of breast cancer in Tunisian women.

Methods: This retrospective study concerned data of 966 breast cancer cases collected from 2007 to 2009 at Salah Azaiz Institute of Tunis. These cases were classified by an immunohistochemistry test for estrogen and progesterone receptors and human epidermal growth factor receptor 2 (HER2) status in the four molecular subtypes, namely luminal A, luminal B, HER2+ and triple negative.

[Epidemiological profile, etiological diagnosis and prognosis of uterine synechias: report of 86 cases].

Background: Uterine synechias may pose real problems for fertility prognosis. It depends mainly on its etiology.

Aim: To study the epidemiological profile of patients, describe the circumstances of discovery of uterine synechias, specify the diagnostic procedures for pelvic ultrasound, hysterography and hysteroscopy and estimate the benefits on fertility.

[Neonatal respiratory morbidity after elective cesarean section at term].

Background: Incidence of elective caesareans at term is increasing these last decades with an associated increase of neonatal respiratory morbidity.

Aim: To analyse the influence of elective Caesarean delivery at term on the incidence of neonatal respiratory distress in order to propose an effective strategy of prevention.

Methods: It is an analytical study compiling all births resulting from elective Caesarean at term (gestational age ranging between 37 and 41+6 GA), reported over two years period at the Charles Nicolle hospital (Tunis-Tunisia).

Pallister-Killian syndrome with additional manifestations of cleft palate and sacral appendage.

Aim: Reppor of a rare congenital abnormalities.

Observation: We report a rare case of Pallister-Killian syndrome in a 33 weeks gestation infant. In addition to the characteristic phenotype, this patient had a cleft palate, diaphragmatic hernia and sacral appendage.

[Neonatal screening of congenital toxoplasmosis. Prospective study].

Background: While toxoplasmosis infection in women is often benign, transmission of maternal infection to the fetus can lead to severe sequelae. Because the majority of patients with acute toxoplasmosis are asymptomayic, a systematic serologic screening program will needed with monthly serologic screening of all seronegative pregnant women until delivery. The aim of this study was to identify cases of congenital toxoplasmosis among all live births of women found to be seronegative in pregnancy once at least.

[Neonatal prognosis of second twin].

Background: Twin pregnancy is associated to high neonatal morbidity particularly for the second twin.

Aim: To assess twin delivery practice in our department and prognosis of second twin.

Methods: Retrospective study of medical files of parturition women with twin pregnancy between January 2003 and December 2006.

Conservative management of cervical pregnancy. A case-report.

Background: cervical pregnancy is one of the rarest ectopic locations. It can be responsible of spontaneous haemorrhage enquiring hysterectomy. Ultrasonography technical improvements allow early diagnosis and conservative treatment.

[Diagnostic value of immunohistochemistry in ovarian sex cord-stromal tumors].

Background: The ovarian tumors' diagnosis is based on biological and radiologic tests but only the histological examination associated to an immunohistochemical study allow best diagnosis.

Aim: The purposes of this study is to examine inhibin and other markers immunoreactivity to ovarian sex cord-stromal tumors and their histological mimics and to discuss its value in the differential diagnosis.

Methods: We report a retrospective study of 31 cases of ovarian sex cord-stromal tumors and review the clinical, pathologic and immunohistochimical features of these tumors.

[Accuracy of frozen section diagnosis: an analysis of 1695 consecutive cases].

Background: The intraoperative frozen section is a well established procedure for rapid diagnosis that helps in making therapeutic decisions.

Aim: Assessment of the accuracy of frozen section diagnosis and analysis of the causes of its discordance.

Methods: A retrospective review of 1695 surgical specimens performed in 1207 patients between January 2002 and April 2005.

[Management of pheochromocytoma during pregnancy: about three cases].

Background: Pheochromocytoma is a rare disease that can be diagnosed for the first time during pregnancy. Diagnosis is difficult because it can mimic common gravid hypertension. Maternal and fetal prognosis depends on early diagnosis and adequate multidisciplinary management.

[Early-onset neonatal bacterial infections: a retrospective series of 144 cases].

Background: Early-onset neonatal bacterial infections continue to be a major cause of morbidity and mortality in the newborn. THE AIM of this study was to determine the incidene, the risk factors and bacterial epidemiology of these infections.

Methods: All cases of early-onset neonatal bacterial infections were identified for the years 2001-2003 using data from obstetric and neonatal reports at the neonatal unit of Charles Nicolle Hospital.

[Adenomyosis at hysterectomy].

Background: adenomyosis is a frequent gynecologic pathology which affects women particularly in the fifth decade. It is responsible of abnormal uterine bleeding and pelvic pain. The diagnosis can be difficult especially when it's associated to other gynaecologic pathologies.