Mitochondrial dysfunction, oxidative stress and apoptotic induction in microglial BV-2 cells treated with sodium arsenate.

The treatment of microglial BV-2 cells with sodium arsenate (As(V): 0.1-400μmol/L - 48hr) induces a dose-dependent response. The neurotoxic effects of high concentrations of As(V) (100, 200 and 400μmol/L) are characterized by increased levels of mitochondrial complexes I, II, and IV followed by increased superoxide anion generation.

Induction by arsenate of cell-type-specific cytotoxic effects in nerve and hepatoma cells.

The aim of the study was to compare the effect of sodium arsenate (AsV) on two different cell types: 158N murine oligodendrocytes and HepG2 human hepatoma cells. Exposure of 158N cells to AsV (0.1-400 µM; 48 h) induced a biphasic cytoxic effect defined as hormesis.

Evidence of hormesis on human neuronal SK-N-BE cells treated with sodium arsenate: impact at the mitochondrial level.

Exposure of human neuronal SK-N-BE cells to sodium arsenate (AsV 0.1-400 μM; 48 h) induced a biphasic toxic effect evoking hormesis. Indeed, at low concentrations, AsV stimulates cell proliferation visualized by phase contrast microscopy, whereas at high concentrations, an induction of cell death associated with a loss of cell adhesion was observed.

Sodium arsenate induce changes in fatty acids profiles and oxidative damage in kidney of rats.

Six groups of rats (n = 10 per group) were exposed to 1 and 10 mg/l of sodium arsenate for 45 and 90 days. Kidneys from treated groups exposed to arsenic showed higher levels of trans isomers of oleic and linoleic acids as trans C181n-9, trans C18:1n-11, and trans C18:2n-6 isomers. However, a significant decrease in eicosenoic (C20:1n-9) and arachidonic (C20:4n-6) acids were observed in treated rats.

Effects of sodium arsenate exposure on liver fatty acid profiles and oxidative stress in rats.

The present study aimed to evaluate the effect of arsenic on liver fatty acids (FA) composition, hepatotoxicity and oxidative status markers in rats. Male rats were randomly devised to six groups (n=10 per group) and exposed to sodium arsenate at a dose of 1 and 10 mg/l for 45 and 90 days. Arsenate exposure is associated with significant changes in the FA composition in liver.

Nutritional aspects of idiopathic nephrolithiasis in Tunisian children.

Objective: We evaluated the metabolic and the nutritional aspects of 134 urolithiasic children, in order to outline the risk factors that contribute to idiopathic stone formation in children.

Material And Methods: In this prospective study 134 children (56 females, 78 males) with renal calculi were evaluated. The age of the patients ranged 6 months to 16 years.

Effect of vitamin A supplemented diet on calcium oxalate renal stone formation in rats.

Objectives: To study the effect of a vitamin A supplemented diet on calcium-oxalate stone formation in rats and to test its expected action in the dissolution of renal calculi.

Material And Methods: Twenty-four male Wistar rats were randomly divided into three groups of eight rats each. The first group (group A) received a normal diet for six weeks.

Accumulation of cadmium and its effects on testis function in rats given diet containing cadmium-polluted radish bulb.

The aim of this study was to examine the accumulation of cadmium (Cd) incorporated in radish bulb and its effects on testes function in male rats. Control animals were given diet containing ordinary radish bulb for 4, 8 and 12 weeks, while contaminated animals were given diet containing Cd-polluted radish bulb (1.1 microg Cd/g of diet) for the same periods as in controls.

Accumulation of cadmium and its effects on liver and kidney functions in rats given diet containing cadmium-polluted radish bulb.

The aim of this study was to examine the accumulation of cadmium (Cd) incorporated in radish bulb and its effects on liver and kidney functions in male rats. Control animals were given diet containing ordinary radish bulb for 4, 8 and 12 weeks, while contaminated animals were given diet containing Cd-polluted radish bulb (1.1 microg Cd/g of diet) for the same periods as in controls.

Influence of hypercalcic and/or hyperoxalic diet on calcium oxalate renal stone formation in rats.

Objective: To test whether increasing dietary calcium intake prevents calcium oxalate stone formation when the diet is oxalate-rich. Material and methods. Four groups, eight rats in each, were subjected to a lithogenic diet by the addition of 0.

Lactational transfer of cadmium from Meriones shawi shawi mothers to their pups and its effects on calcium homeostasis and bone calcium in pups.

Cadmium (Cd) was given to Meriones shawi shawi dams in the diet (1 g CdCl2/1.5 kg of diet) from day 1 to day 21 of lactation. Pups were killed at 5, 10, 14 and 21 days of lactation.