Cephalic arch stenosis: mechanisms and management strategies.

Cephalic arch is a frequent site for the development of stenosis in patients with brachiocephalic fistulae. This is in part owing to the anatomic constraints of the cephalic arch region and the exertion of hemodynamic forces at this site caused by the creation of a brachiocephalic fistula. Multiple interventions have been used to correct stenosis and subsequent fistula dysfunction.

At-home short daily hemodialysis improves the long-term health-related quality of life.

Patients with chronic kidney disease treated by in-center conventional hemodialysis (3 times per week) have significant impairments in health-related quality of life measures, which have been associated with increased morbidity and mortality. FREEDOM is an ongoing prospective cohort study measuring the potential benefits of at-home short daily (6 times per week) hemodialysis. In this interim report we examine the long-term effect of short daily hemodialysis on health-related quality of life, as measured by the SF-36 health survey.

Ertapenem pharmacokinetics and pharmacodynamics during continuous ambulatory peritoneal dialysis.

Scant data exist for the pharmacokinetics (PK) of ertapenem in patients on continuous ambulatory peritoneal dialysis (CAPD). The goals of this study were to characterize the PK profile of ertapenem during CAPD, determine the extent of ertapenem penetration into the peritoneal cavity, and quantify the probability of the target attainment (PTA) profile in the serum and peritoneal cavity. A single-dose PK study was conducted in seven patients on CAPD.

Impact of short daily hemodialysis on restless legs symptoms and sleep disturbances.

Background And Objectives: Restless legs syndrome (RLS) and sleep disturbances are common among in-center hemodialysis patients and are associated with increased morbidity/mortality.

Design, Setting, Participants, & Measurements: The FREEDOM study is an ongoing prospective cohort study investigating the benefits of home short daily hemodialysis (SDHD) (6 times/week). In this interim report, we examine the long-term effect of SDHD on the prevalence and severity of RLS, as measured by the International Restless Legs Syndrome (IRLS) Study Group rating scale, and sleep disturbances, as measured by the Medical Outcomes Study sleep survey.

The safety and efficacy of an accelerated iron sucrose dosing regimen in patients with chronic kidney disease.

Background: Provision of adequate iron to support erythropoiesis in patients with chronic kidney disease (CKD) is time consuming and may present adherence problems for patients in the outpatient setting. We studied an accelerated regimen of high-dose intravenous iron sucrose therapy in a cohort of iron-deficient, anemic CKD patients.

Methods: Intravenous iron sucrose 500 mg was infused over three hours on two consecutive days in 107 CKD patients (glomerular filtration rate, 32.