Publications by authors named "Rachid Attou"
Increased circulating histones correlate with sepsis severity and are a potential therapeutic target. Pre-clinical studies showed benefit with a histone-neutralizing polyanion molecule (STC3141). We aimed to investigate the safety, tolerability, and pharmacokinetics of STC3141 in critically ill patients with sepsis.
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- Primary bone lymphoma of the spine (PBL) is a rare condition that can be misdiagnosed due to its similarities with infections and other diseases.
- The case involves a woman in her sixties with chronic low back pain and cruralgia, leading to various imaging tests that suggested spondylodiscitis but ultimately identified aggressive diffuse large B-cell lymphoma.
- This case emphasizes the challenges in diagnosing PBL, as both PBL and infections display similar symptoms and imaging characteristics, making accurate differentiation essential for proper treatment.
Invasive aspergillosis (IA) represents a common form of fungal infection caused by various species of that most frequently affect immunocompromised patients. Typically, this disease occurs preferentially in high-risk groups including patients infected with the human immunodeficiency virus (HIV), patients with leukemia, patients with autoimmune diseases, and organ transplant patients undergoing medical immunosuppression. Considered the second most common cause of opportunistic fungal infection in humans after , this pathogen predominantly affects the lungs, but it may also spread by a hematogenous route to various organs and have a heterogeneous presentation.
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- TAFRO syndrome is a rare disease with symptoms like low blood platelets, swelling all over, fever, changes in bone marrow, and swollen organs.
- It was first identified in Japan in 2010, and doctors aren't sure exactly what causes it, but it can be linked to various health issues.
- A recent case showed that using a special scan called 18F-FDG-PET/CT can help diagnose and manage this syndrome better.
Background: Patients with severe respiratory failure due to COVID-19 who are not under mechanical ventilation may develop severe hypoxemia when complicated with spontaneous pneumomediastinum (PM). These patients may be harmed by invasive ventilation. Alternatively, veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) may be applied.
View Article and Find Full Text PDFBackground: Limiting the fluid bolus (FB) volume may attenuate side effects, including hemodilution and increased filling pressures, but it may also reduce hemodynamic responsiveness. The minimum volume to create hemodynamic effects is considered to be 4 mL/kg. In critically ill patients, the hemodynamic effects of FB with this volume have not been adequately investigated and compared to higher quantities.
View Article and Find Full Text PDFIn this chapter, anticoagulation treatments for adsorption techniques in continuous renal replacement therapy (CKRT) will be reviewed. Anticoagulation used with adsorption techniques is quite different than anticoagulation in classical CKRT with nonadsorptive therapies. Regional citrate anticoagulation (RCA) and unfractionated heparin (UFH) are the most common anticoagulation modalities for both nonselective adsorptive membranes - such as surface-treated acrylonitrile 69 membranes (AN69ST) and polymethylmethacrylate membranes - and selective adsorptive membranes such as AN69-oXiris.
View Article and Find Full Text PDFBackground: High ratio of the carbon dioxide veno-arterial difference to the oxygen arterial-venous difference (PCO/CO) is associated with fluid bolus (FB) induced increase in oxygen consumption (VO). This study investigated whether PCO/CO was associated with decreases in blood-lactate levels FB in critically ill patients with hyperlactatemia.
Methods: This prospective observational study examined adult patients in the intensive care unit (ICU) with lactate levels > 1.