Publications by authors named "Rachelle Wolk"
With the advancement of molecular testing and the routine use of immunohistochemical stains, salivary gland tumours previously categorized as adenoma or adenocarcinoma, not otherwise specified, are being reclassified with distinct diagnoses. Newly recognized benign entities include: sclerosing polycystic adenoma, keratocystoma, intercalated duct hyperplasia and adenoma, and striated duct adenoma. Newly recognized malignant salivary gland tumours include: microsecretory adenocarcinoma, sclerosing microcytic adenocarcinoma, and mucinous adenocarcinoma.
View Article and Find Full Text PDFImportance: Immune checkpoint inhibitors improve survival in recurrent and/or metastatic head and neck cancer, yet their role in curative human papillomavirus-positive oropharyngeal cancer (HPV+ OPC) remains undefined. Neoadjuvant nivolumab and chemotherapy followed by response-adaptive treatment in HPV+ OPC may increase efficacy while reducing toxicity.
Objective: To determine the deep response rate and tolerability of the addition of neoadjuvant nivolumab to chemotherapy followed by response-adapted locoregional therapy (LRT) in patients with HPV+ OPC.
Autoinfarction of a parathyroid adenoma can have an atypical clinicoradiologic features that can mimic an inflammatory process or malignancy. In addition, the associated fibrosis makes surgical resection more challenging than for regular parathyroid adenomas. The implications of these findings are that while autoinfarction of parathyroid adenomas is a rare phenomenon, this entity should be considered when there are heterogeneous and cystic components on imaging in patients without hypercalcemia.
View Article and Find Full Text PDFArticle Synopsis
- Artificial intelligence, particularly deep neural networks (DNN), can classify tumors from histology samples quickly and accurately, often matching or surpassing human pathologists' abilities.
- There is a challenge in understanding how these neural networks make their predictions, but new explainability tools are being developed, including the use of synthetic histology created by conditional generative adversarial networks (cGAN).
- The synthetic histology not only helps visualize key histologic features linked to tumor molecular types but also enhances the training of pathologists by providing intuitive visual aids for better understanding tumor biology.
Head and neck squamous cell carcinoma (HNSCC) is the world's 6th most common malignancy. Oral cavity SCC (OCSCC) represents approximately one third of the HNSCC cases diagnosed annually in the United States. Despite therapeutic advances, OCSCC is frequently lethal, with a modest 5-year survival.
View Article and Find Full Text PDFAtypical herpetic ulcerations in COVID-19 positive patients: A report of three cases.
Oral Surg Oral Med Oral Pathol Oral Radiol
February 2023
Article Synopsis
- * This report discusses three hospitalized COVID-19 patients who developed unusual herpetic ulcerations while receiving remdesivir and steroids, which are more common in immunocompromised individuals.
- * The ulcerations observed in these patients are different from typical herpes infections, prompting the authors to raise awareness for early diagnosis and to highlight the potential immunocompromised status of COVID-19 patients undergoing treatment.