Publications by authors named "Rachele Scotton"
Background: The Control to Range Study was a multinational artificial pancreas study designed to assess the time spent in the hypo- and hyperglycemic ranges in adults and adolescents with type 1 diabetes while under closed-loop control. The controller attempted to keep the glucose ranges between 70 and 180 mg/dL. A set of prespecified metrics was used to measure safety.
View Article and Find Full Text PDFAims/hypothesis: Chronic foot ulceration is a severe complication of diabetes, driving morbidity and mortality. The mechanisms underlying delaying wound healing in diabetes are incompletely understood and tools to identify such pathways are eagerly awaited.
Methods: Wound biopsies were obtained from 75 patients with diabetic foot ulcers.
Article Synopsis
- This study examines the effectiveness of model predictive control (MPC) in a wearable artificial pancreas (AP) for managing postprandial glucose levels in type 1 diabetes patients in an outpatient setting.
- Six participants were tested over 42 hours, comparing sensor-augmented pump therapy with closed-loop MPC, showing significant improvement in glucose control during meals and overnight.
- The findings indicate that MPC strategies are promising for outpatient glucose management, suggesting further research through randomized crossover studies.
Objective: To compare two validated closed-loop (CL) algorithms versus patient self-control with CSII in terms of glycemic control.
Research Design And Methods: This study was a multicenter, randomized, three-way crossover, open-label trial in 48 patients with type 1 diabetes mellitus for at least 6 months, treated with continuous subcutaneous insulin infusion. Blood glucose was controlled for 23 h by the algorithm of the Universities of Pavia and Padova with a Safety Supervision Module developed at the Universities of Virginia and California at Santa Barbara (international artificial pancreas [iAP]), by the algorithm of University of Cambridge (CAM), or by patients themselves in open loop (OL) during three hospital admissions including meals and exercise.
Objective: To evaluate the feasibility of a wearable artificial pancreas system, the Diabetes Assistant (DiAs), which uses a smart phone as a closed-loop control platform.
Research Design And Methods: Twenty patients with type 1 diabetes were enrolled at the Universities of Padova, Montpellier, and Virginia and at Sansum Diabetes Research Institute. Each trial continued for 42 h.
Background And Aims: The aim of this study was to compare blood glucose and plasma insulin profiles after bolus insulin infusion by a patch pump (PP) versus a conventional pump (CP), directly after placement and after Day 3 of use.
Patients And Methods: Twenty patients with type 1 diabetes came in for two blocks of visits: one block of two visits while wearing the OmniPod® (Insulet Corp., Bedford, MA) insulin pump (PP) and one block of two visits while wearing the Medtronic Diabetes (Northridge, CA) Paradigm® pump (CP).