Publications by authors named "Rachele Santori"
Article Synopsis
- A study evaluated the use of a portable low-frequency ultrasound device to screen for skeletal fragility in postmenopausal women with primary hyperparathyroidism (PHPT) before conducting DXA scans.
- Results showed a moderate agreement between radius measurements from the ultrasound and DXA, with lower ultrasound T-scores correlating with higher osteoporosis risk at lumbar and femoral sites.
- The findings suggest that this ultrasound tool could be a useful alternative for assessing fracture risk in situations where DXA scans are not feasible.
Evaluating adherence, tolerability and safety of oral calcium citrate in elderly osteopenic subjects: a real-life non-interventional, prospective, multicenter study.
Aging Clin Exp Res
February 2024
Background: Osteoporosis is a common concern in the elderly that leads to fragile bones. Calcium supplementation plays a crucial role in improving bone health, reducing fracture risk, and supporting overall skeletal strength in this vulnerable population. However, there is conflicting evidence on the safety of calcium supplements in elderly individuals.
View Article and Find Full Text PDFFGF23 functions and disease.
Minerva Endocrinol (Torino)
December 2022
The main function of fibroblast growth factor 23 (FGF23) is the regulation of phosphate metabolism through its action on the sodium-dependent phosphate cotransporters in the proximal renal tubules. Additionally, FGF23 interacts with vitamin D and parathyroid hormone in a complex metabolic pathway whose detailed mechanisms are still not clear in human physiology and disease. More recently, research has also focused on the understanding of mechanisms of FGF23 action on organs and system other than the kidneys and bone, as well as on its interaction with other metabolic pathways.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze echocardiographic parameters in postmenopausal women with normocalcemic primary hyperparathyroidism (NCPHPT) compared to those with hypercalcemic primary hyperparathyroidism and healthy controls.
- Results showed that women with hypercalcemic PHPT had significantly altered calcium and parathyroid hormone levels, while NCPHPT patients displayed higher phosphorus but similar cardiovascular risk factors and echocardiographic outcomes compared to controls.
- The findings suggest no significant differences in heart health metrics among the groups, indicating that NCPHPT may not impact cardiovascular parameters as seen in patients with hypercalcemic PHPT.
Purpose: To evaluate clinical features, treatments, and outcomes of osteoporotic patients admitted to internal medicine and geriatric wards compared with non-osteoporotic patients (REPOSI registry).
Methods: We studied 4714 patients hospitalized between 2010 and 2016. We reported age, sex, educational level, living status, comorbidities and drugs taken, Cumulative Illness Rating Scale (CIRS), Barthel Index, Short-Blessed Test, 4-item Geriatric Depression Scale, serum hemoglobin, creatinine, and clinical outcomes.
The multiple endocrine functions of bone other than those related to mineral metabolism, such as regulation of insulin sensitivity, glucose homeostasis, and energy metabolism, have recently been discovered. and murine studies investigated the impact of several molecules derived from osteoblasts and osteocytes on glucose metabolism. In addition, the effect of glucose on bone cells suggested a mutual cross-talk between bone and glucose homeostasis.
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