Publications by authors named "Rachel Zolno"
Article Synopsis
- There is evidence of a prodromal phase in pediatric-onset multiple sclerosis (POMS), marked by increased health care utilization prior to the first demyelinating event (FDE).
- In a study analyzing 37 POMS cases over two years before FDE, it was found that health care interactions increased significantly in the year prior (B) compared to the year before (A), including a notable rise in neurology-related encounters.
- The most common symptoms reported were neurological, particularly headaches, along with psychiatric and various non-neurological issues, highlighting the complexity of POMS symptoms leading up to FDE.
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has been implicated in a wide range of CNS encephalitis and myelitis presentations. We present a previously healthy 16-year-old girl who presented with acute onset headaches that rapidly progressed to encephalopathy, flaccid paraparesis, lower extremity hyperreflexia, and urinary retention. Serial MRI brain and total spine imaging demonstrated evolving diffuse supratentorial leptomeningeal enhancement and holocord gray matter restricted T2 bright lesion without enhancement.
View Article and Find Full Text PDFWe outline the case of a 6-year-old girl presenting with a 2-week course of waxing and waning neurologic symptoms, including right-sided pain, weakness, dizziness, and difficulty walking. Her examination was notable for right-sided weakness, hyperreflexia, and dysmetria. Diagnostic evaluation was significant for MRI with numerous T2 hyperintense, T1 hypointense, and T1-enhancing lesions located in the juxtacortical and periventricular regions, corpus callosum, brainstem, and spinal cord; positive CSF oligoclonal bands; negative serum aquaporin-4 immunoglobulin G (IgG) and myelin oligodendrocyte glycoprotein IgG; and positive serum Epstein-Barr viral capsid antigen IgG.
View Article and Find Full Text PDF