Publications by authors named "Rachel W Chevalier"
Oral delivery of therapeutics is the preferred route for systemic drug administration due to ease of access and improved patient compliance. However, many therapeutics suffer from low oral bioavailability due to low pH and enzymatic conditions, poor cellular permeability, and low residence time. Microfabrication techniques have been used to create planar, asymmetric microdevices for oral drug delivery to address these limitations.
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- - The oral route is the best method for delivering drugs to the gastrointestinal (GI) tract, but many drugs struggle with absorption due to enzymes, pH levels, and tissue barriers.
- - To improve absorption, researchers created micron-scale devices called microdevices that attach to the GI lining and release drugs directly, using nanostraw membranes to seal and enhance these devices.
- - The nanostraw membranes help with drug loading, control how drugs are released, prevent external interference, and improve the adhesion of devices to GI tissue, indicating their potential for better oral drug absorption.