Combination of obstructive sleep apnoea and insomnia treated by continuous positive airway pressure with the SensAwake pressure relief technology to assist sleep: a randomised cross-over trial protocol.

Introduction: Obstructive sleep apnoea (OSA) is a common sleep breathing disorder affecting up to 17% of the middle-aged population. Continuous positive airway pressure (CPAP) is the primary treatment for patients with OSA, but acceptance and adherence to therapy is suboptimal in specific subgroups particularly those with insomnia or poor sleep quality (40%-80% of patients with OSA). Pressure intolerance, particularly during periods of wakefulness, inhibiting sleep onset or return to sleep, is one reason for poor CPAP adherence.

The effect of anterior-posterior shear on the wear of CHARITÉ total disc replacement.

Study Design: An in vitro study of the wear rates of the CHARITÉ lumbar total disc replacement (TDR).

Objective: To investigate the effect of anterior-posterior shear on the in vitro wear rates of the CHARITÉ lumbar TDR.

Summary Of Background Data: Current standards prescribe only 4-degrees of freedom (DOF) inputs for evaluating the in vitro wear of TDRs, despite the functional spinal unit incorporating 6 DOF.

Preferential superior surface motion in wear simulations of the Charité total disc replacement.

Laboratory wear simulations of the dual-bearing surface Charité total disc replacement (TDR) are complicated by the non-specificity of the device's center of rotation (CoR). Previous studies have suggested that articulation of the Charité preferentially occurs at the superior-bearing surface, although it is not clear how sensitive this phenomenon is to lubrication conditions or CoR location. In this study, a computational wear model is used to study the articulation kinematics and wear of the Charité TDR.