Docosahexaenoic Acid Controls Pulmonary Macrophage Lipid Raft Size and Inflammation.

Background: Docosahexaenoic acid (DHA) controls the biophysical organization of plasma membrane sphingolipid/cholesterol-enriched lipid rafts to exert anti-inflammatory effects, particularly in lymphocytes. However, the impact of DHA on the spatial arrangement of alveolar macrophage lipid rafts and inflammation is unknown.

Objectives: The primary objective was to determine how DHA controls lipid raft organization and function of alveolar macrophages.