Moderate statin treatment reduces prebeta-1 high-density lipoprotein levels in dyslipidemic patients.

Background: Elevated plasma levels of prebeta-1 high-density lipoprotein (HDL), the principal acceptor of cholesterol effluxed from macrophages, are associated with increased risk of atherosclerotic coronary heart disease and myocardial infarction.

Objective: The objective of the study was to assess the effects on prebeta-1 HDL levels of 6-week moderate-dose statin treatment.

Methods: We studied 101 patients (mean age 52.

Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons.

L-type voltage gated calcium channels have an important role in neuronal development by promoting dendritic growth and arborization. A point mutation in the gene encoding Ca(V)1.2 causes Timothy syndrome, a neurodevelopmental disorder associated with autism spectrum disorders (ASDs).