Publications by authors named "Rachel Pei-Jen Lai"
Globally, about 36.7 million people were living with HIV infection at the end of 2015. The most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis-374,000 deaths per annum are attributable to HIV-tuberculosis, 75% of those occurring in Africa.
View Article and Find Full Text PDFIncreased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site.
Willy M J M Bogers Susan W Barnett Herman Oostermeijer Ivonne G Nieuwenhuis Niels Beenhakker Rachel Pei-Jen Lai
J Virol
October 2017
Article Synopsis
- The study focuses on enhancing the immune response to HIV-1 envelope antigens in order to create more effective and long-lasting vaccines, as current responses are weak and short-lived.* ! -
- The researchers blocked the CD4 binding site of the HIV-1 gp140 antigen using a mimetic miniprotein, leading to better B-cell responses and antibody-dependent cellular cytotoxicity in rhesus macaques.* ! -
- This new approach resulted in quick and durable B-cell responses that lasted over 60 weeks, addressing previous challenges in developing effective HIV vaccines.* !