Long COVID-19 outcomes of patients with pre-existing dementia.

Background: Although COVID-19 has been linked to worse acute outcomes in patients with some neurodegenerative disorders, its long-term impact on dementia remains unclear.

Objective: To investigate the outcomes of COVID-19 survivors with dementia.

Methods: This retrospective study evaluated 9806 patients with dementia in the Montefiore Health System (January 2016 to July 2023).

Threshold inclusion size triggers conversion of huntingtin to prion-like state that is reversible in newly born cells.

Aggregation of mutant Huntingtin protein (mHtt) leads to neuronal cell death and human disease. We investigated the effect of inclusion formation on yeast cells. Previous work indicates that mHtt protein moves both in and out of inclusions, potentially undergoing refolding in the inclusion.