Publications by authors named "Rachel P Chirayil"
Proc Natl Acad Sci U S A
August 2018
Article Synopsis
- About 70% of people infected with hepatitis C virus (HCV) develop chronic infections, increasing their risk for severe liver disease, including cancer.
- Research reveals that the DUSP11 enzyme makes HCV transcripts vulnerable to degradation by XRN exonucleases, which help combat HCV replication.
- In cells that lack DUSP11, HCV replication increases significantly, and the role of the microRNA miR-122, which protects HCV transcripts, becomes less critical.
