Publications by authors named "Rachel O Currin"
J Biol Chem
September 2008
Article Synopsis
- - Rho GTPases, part of the Ras superfamily, play crucial roles in various biological functions and are linked to cancer and other diseases, with 20 known members in humans.
- - The functional diversity of these GTPases is influenced by specific posttranslational modifications at their CAAX motifs, which dictate their subcellular localization and activity.
- - Research using pharmacologic, biochemical, and genetic methods shows that while classical Rho GTPases are generally modified by one type of lipid, most other members prefer a different modification, revealing potential targets for new cancer therapies.
