Isolation and characterization of the decreased cuticular penetration mechanism of fluralaner resistance in the house fly, Musca domestica.

Decreased cuticular penetration has been documented as a mechanism of resistance in several insects, yet this mechanism remains poorly understood. Levels of resistance conferred, effects of the physicochemical properties on the manifestation of resistance and the effects of different routes of exposure are largely unknown. We recently selected a strain (FlurR) of house fly that was >11,000-fold resistance to fluralaner, and decreased cuticular penetration was one of the mechanisms of resistance (Norris et al.

Small- to medium-sized mammals show greater morphological disparity in cervical than lumbar vertebrae across different terrestrial modes of locomotion.

During mammalian terrestrial locomotion, body flexibility facilitated by the vertebral column is expected to be correlated with observed modes of locomotion, known as gait (e.g., sprawl, trot, hop, bound, gallop).

Selection and characterization of spinetoram resistance in field collected Drosophila melanogaster.

Insecticides are commonly employed in vineyards to control vinegar flies and limit sour rot disease. Widespread resistance to available insecticides is having a negative impact on managing Drosophila melanogaster populations, rendering control of sour rot more difficult. An insecticide registered for use in vineyards to which resistance is not yet widespread (at least in New York and Missouri) is spinetoram.

Are America's Caregivers on the Brink of Extinction? The Pandemic Straw that Broke the Nurses' Back.

The coronavirus disease 2019 pandemic has drawn attention to many of the inadequacies of the US health-care system. Perhaps, no profession has felt these shortcomings more than nurses. This female-dominated profession has the potential to suffer a high attrition rate for several reasons, including declining mental health and increasing workplace violence.

Selection for, and characterization of, fluralaner resistance in the house fly, Musca domestica.

House flies, Musca domestica (L), are the mechanical vector of >100 human and animal pathogens, including those that are antibiotic-resistant. Given that house flies are associated closely with human and livestock activity, they present medical and veterinary health concerns. Although there are numerous strategies for control of house fly populations, chemical control has been favored in many facilities.

A single centre evaluation of the 2019 UK SABR consortium guidelines for primary lung cancer: correlation between Prescription Dose Spillage and inverse Paddick Conformity Index.

Background: The aim of the study was to determine level of agreement between RTOG Conformity Index (RTOG-CI), Paddick Conformity Index (PCI) and Prescription Dose Spillage (PDS) in describing lung stereotactic ablative radiotherapy (SABR) plan conformity; to elucidate any limitations, in practice, of PCI and PDS. International Commission on Radiation Units and Measurements report 91 (ICRU 91) aimed to reduce inconsistencies in dose prescription and normalisation between centres by specifying SABR reporting rules, and suggested using PCI. UK SABR Consortium 2019 guidelines adopted PDS to measure plan quality, but not the PCI.

Insecticide resistance in Drosophila melanogaster in vineyards and evaluation of alternative insecticides.

Background: Cultivation of grapes is a major crop globally, particularly in support of the wine production industry which has significant economic impact in numerous countries. Sour rot is an economically important disease of grapes. It is caused by an interaction of yeast + acetic acid bacteria, and vectored by Drosophila spp.

Individual Attributes, Values, and Goals of an All-Military Women Antarctic Expedition.

While participation of women in the military has increased, research on performance of female teams engaged in arduous physical activity in isolated, confined, and extreme (ICE) environments remains sparse. A team of six British military women completed the Multidimensional Personality Questionnaire-Brief Form, Triarchic Psychopathy Measure, and Personal Values Questionnaire (PVQ) prior to embarking on an expedition that traversed the Antarctic continent. Questionnaires were completed weekly on the ice; repeat of the PVQ and individual semistructured debriefing interviews were carried out within 9 d post-expedition.

Defence Clinical Psychology Service: an overview of clinical psychology in the UK Ministry of Defence.

The Defence Clinical Psychology Service (DCPS) is the professional clinical psychology service and community of clinical psychology practice within UK Ministry of Defence (MoD). The DCPS provides professional clinical care, consultation and research in support of the UK Armed Forces. Regulated by the Health and Care Professions Council, DCPS psychologists are employed as Crown (Civil) Servants within the MoD.

Leadership in 21st century military healthcare: what did clinical psychologists ever do for us?

Psychology is integral to the concepts and practice of leadership. Leadership models often have their roots in psychological paradigms, making it intrinsically easy for psychologists to grasp and apply them alongside clinical models. Psychologists' 'second-order' skills have been used to good effect in the changing landscape of military mental healthcare: modelling adaptive responses to change, understanding the non-conscious aspects of relationships in hierarchical organisations, working with systems, the ability to diagnose situational requirements and act accordingly, drawing on a range of psychological theories and leadership styles.

Resolving plasmid structures in using the MinION nanopore sequencer: assessment of MinION and MinION/Illumina hybrid data assembly approaches.

This study aimed to assess the feasibility of using the Oxford Nanopore Technologies (ONT) MinION long-read sequencer in reconstructing fully closed plasmid sequences from eight isolates of six different species with plasmid populations of varying complexity. Species represented were , , , and , with plasmid populations ranging from 1-11 plasmids with sizes of 2-330 kb. Isolates were sequenced using Illumina (short-read) and ONT's MinION (long-read) platforms, and compared with fully resolved PacBio (long-read) sequence assemblies for the same isolates.

Maternally induced intraclutch cannibalism: an adaptive response to predation risk?

Theory on condition-dependent risk-taking indicates that when prey are in poor condition, their anti-predator responses should be weak. However, variation in responses resulting from differences in condition is generally considered an incidental by-product of organisms living in a heterogeneous environment. Using Leptinotarsa decemlineata beetles and stinkbug (Podisus maculiventris) predators, we hypothesised that in response to predation risk, parents improve larval nutritional condition and expression of anti-predator responses by promoting intraclutch cannibalism.

Adaptation of EPEC-EM Curriculum in a Residency with Asynchronous Learning.

Objective: The Education in Palliative and End-of-life Care for Emergency Medicine Project (EPEC™-EM) is a comprehensive curriculum in palliative and end-of-life care for emergency providers. We assessed the adaptation of this course to an EM residency program using synchronous and asynchronous learning.

Methods: Curriculum adaptation followed Kern's standardized six-step curriculum design process.

Does sexual dimorphism in facial soft tissue depths justify sex distinction in craniofacial identification?

Separation of male and female soft tissue depths into discrete groups for craniofacial identification implies that males and females differ enough from each other, with respect to this application, for this distinction to be useful. In this study, previously published soft tissue depth data were analyzed for sex separation. It was found that the variation within each sex was large while the variation between the sexes was small.

Dementia caregiver intervention research: in search of clinical significance.

Purpose: We reviewed intervention studies that reported dementia caregiver outcomes published since 1996, including psychosocial interventions for caregivers and environmental and pharmacological interventions for care recipients. Our goal was to focus on issues of clinical significance in caregiver intervention research in order to move the field toward a greater emphasis on achieving reliable and clinically meaningful outcomes.

Design And Methods: MEDLINE, PsycINFO, and Cumulative Index to Nursing & Allied Health databases from 1996 through 2001 were searched to identify articles and book chapters mapping to two medical subject headings: caregivers and either dementia or Alzheimer's disease.