Publications by authors named "Rachel Naomi Curry"
Article Synopsis
- Malignant glioma, a deadly brain cancer, creates an immunosuppressive environment that limits the effectiveness of treatments targeting the immune system.
- Researchers used single-cell RNA sequencing to identify glioma cells expressing CD83, a marker linked to mature immune cells, and studied its effects on tumor growth and immune response in mice and human samples.
- Findings indicate that CD83+ tumor cells may promote anti-tumor activity by enhancing T cell responses and increasing inflammatory signals, suggesting that CD83 could be a potential target for improving immunotherapy in glioma patients.
Seizures are a frequent pathophysiological feature of malignant glioma. Recent studies implicate peritumoral synaptic dysregulation as a driver of brain hyperactivity and tumor progression; however, the molecular mechanisms that govern these phenomena remain elusive. Using scRNA-seq and intraoperative patient ECoG recordings, we show that tumors from seizure patients are enriched for gene signatures regulating synapse formation.
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