Publications by authors named "Rachel Mund"
Article Synopsis
- The Epstein-Barr Virus (EBV) and Kaposi Sarcoma-associated Herpesvirus (KSHV) are both cancer-causing viruses that utilize host cellular mechanisms to promote their replication and the development of cancer.
- EBV infects around 90% of people globally and is linked to several cancers like Burkitt lymphoma and nasopharyngeal carcinoma, manipulating ubiquitin pathways to enhance cell proliferation and evade apoptosis.
- KSHV, responsible for Kaposi's Sarcoma, also employs similar ubiquitin-mediated strategies to degrade tumor suppressors and evade immune responses, making both viruses significant in understanding viral oncogenesis and potential cancer therapies.
Resolution of cohesion between sister telomeres in human cells depends on TRF1-mediated recruitment of the polyADP-ribosyltransferase tankyrase to telomeres. In human aged cells, due to insufficient recruitment of TRF1/tankyrase to shortened telomeres, sisters remain cohered in mitosis. This persistent cohesion plays a protective role, but the mechanism by which sisters remain cohered is not well understood.
View Article and Find Full Text PDFSevoflurane But Not Propofol Provided Dual Effects of Cell Survival in Human Neuroblastoma SH-SY5Y Cells.
Curr Alzheimer Res
November 2021
Background: We have hypothesized that the most commonly used intravenous (propofol) and inhalational (sevoflurane) general anesthetics affect cell survival concentration and duration dependently with different potency associated with their differential potency to affect intracellular Ca+2 homeostasis.
Methods: Human neuroblastoma SH-SY5Y cells stably transfected with either wild type or M146L mutant human presenilin 1 were cultured and exposed to equipotent of propofol or sevoflurane. Cell viability, cytosolic and mitochondrial calcium were measured.
Background: Overactivation of ryanodine receptors and the resulting impaired calcium homeostasis contribute to Alzheimer's disease-related pathophysiology. This study hypothesized that exposing neuronal progenitors derived from induced pluripotent stems cells of patients with Alzheimer's disease to dantrolene will increase survival, proliferation, neurogenesis, and synaptogenesis.
Methods: Induced pluripotent stem cells obtained from skin fibroblast of healthy subjects and patients with familial and sporadic Alzheimer's disease were used.