Gene expression profiling in squamous cell carcinoma of the oral cavity shows abnormalities in several signaling pathways.

Objectives/hypothesis: To examine gene expression profiles in squamous cell carcinoma of the oral cavity (oral SCC) compared with histologically matched normal tissue.

Study Design: Fresh-frozen tissue was prospectively obtained from individuals undergoing surgical resections for oral SCC.

Methods: RNA was extracted from seven sets of oral SCC and matched normal tissue.