Moderate-high intensity exercise associates with reduced incident alcohol-associated liver disease in high-risk patients.

Background: Therapies to prevent alcohol-associated liver disease (ALD) in high-risk patients are needed.

Aims: In this retrospective association study, we examined whether patients with alcohol use disorder (AUD) who reported greater exercise were less likely to develop liver disease.

Methods: In this retrospective cohort study, we used the Mass General Brigham Biobank to investigate the impact of both moderate-high and light-intensity exercise on the development of ALD in patients with AUD, using clinician-provided diagnostic International Classification of Diseases 10 codes.