Targeted-microbubble binding selectively to GPIIb IIIa receptors of platelet thrombi.

Rationale And Objectives: New targeted microbubbles directed to the GPIIb IIIa receptor have been developed. The objective was to determine whether targeting microbubbles to clots would enhance ultrasound imaging. Systematic studies were designed to determine whether in vitro methodology is an acceptable predictor of in vivo efficacy.