Publications by authors named "Rachel M LeMalefant"
Article Synopsis
- Mr. A, a man with mental and physical disabilities, struggles with bipolar disorder, a spinal injury from a car accident, and alcohol addiction, leading to severe neuropsychiatric symptoms.
- Despite treatment efforts, his agitation and mood swings improved, but his cognitive and speech impairments worsened irreversibly in a short time, causing confusion for the medical team.
- Further investigations suggested that his neuropsychiatric issues stemmed from a combination of his bipolar disorder, alcohol-related dementia, and ongoing neurodegeneration, highlighting the complexity of treating such interrelated conditions.
Addiction to nicotine and the inability to quit smoking are influenced by genetic factors, emphasizing the importance of understanding how genes and drugs of abuse mechanistically impact each other. One well-characterized protein responsible for regulating both response to drugs and gene expression is the transcription factor CREB (cAMP-responsive element binding protein). Previous work indicates that hippocampal-specific alterations in CREB signaling and synaptic plasticity may underlie certain nicotine withdrawal phenotypes.
View Article and Find Full Text PDF