Human genetic variation reveals FCRL3 is a lymphocyte receptor for .

is the gram-negative bacterium responsible for plague, one of the deadliest and most feared diseases in human history. This bacterium is known to infect phagocytic cells, such as dendritic cells and macrophages, but interactions with non-phagocytic cells of the adaptive immune system are frequently overlooked despite the importance they likely hold for human infection. To discover human genetic determinants of infection, we utilized nearly a thousand genetically diverse lymphoblastoid cell lines in a cellular genome-wide association study method called Hi-HOST (High-throughput Human in-vitrO Susceptibility Testing).

Human genetic diversity regulating the locus confers increased cytokines in response to .

Human genetic diversity can have profound effects on health outcomes upon exposure to infectious agents. For infections with (), the wide range of genital and ocular disease manifestations are likely influenced by human genetic differences that regulate interactions between and host cells. We leveraged this diversity in cellular responses to demonstrate the importance of variation at the Toll-like receptor 1 (), , and locus to cytokine production in response to .