Gustatory responses of the mouse chorda tympani nerve vary based on region of tongue stimulation.

Different parts of the mouth vary in their taste responsiveness and gustatory transduction components. However, there have been few attempts to consider regional variation among areas innervated by a single nerve branch or containing only one type of gustatory papilla. Here, we examined whether taste-elicited responses of a single nerve, the chorda tympani (CT), depend on where taste solutions are delivered on the tongue in mice.

Salty taste deficits in CALHM1 knockout mice.

Genetic ablation of calcium homeostasis modulator 1 (CALHM1), which releases adenosine triphosphate from Type 2 taste cells, severely compromises the behavioral and electrophysiological responses to tastes detected by G protein-coupled receptors, such as sweet and bitter. However, the contribution of CALHM1 to salty taste perception is less clear. Here, we evaluated several salty taste-related phenotypes of CALHM1 knockout (KO) mice and their wild-type (WT) controls: 1) In a conditioned aversion test, CALHM1 WT and KO mice had similar NaCl avoidance thresholds.