Optimal surveillance strategies for patients with stage 1 cutaneous melanoma post primary tumour excision: three systematic reviews and an economic model.

Background: Malignant melanoma is the fifth most common cancer in the UK, with rates continuing to rise, resulting in considerable burden to patients and the NHS.

Objectives: The objectives were to evaluate the effectiveness and cost-effectiveness of current and alternative follow-up strategies for stage IA and IB melanoma.

Review Methods: Three systematic reviews were conducted.

Within-Person variations in mindfulness mediate effects of daily stressors on psychological distress in adolescence.

Objective: We tested two competing models linking daily stress, mindfulness, and psychological distress in adolescence: 1) whether daily mindfulness moderates the impact of daily stressors on psychological distress or 2) whether mindfulness mediates the relationship between greater daily stressors and psychological distress.

Methods: Every evening for a week, 138 adolescents completed ecological momentary assessments (EMAs). Daily diaries assessed negative events, work-school conflict, mindfulness, and perceived stress.

Nanopore-Based Electrodes for Quinotrione Detection: Host-Guest-Induced Electrochemical Signal Switching.

Nanopore-based detection techniques, with a wide range of transport properties, exhibit impressive selectivity and sensitivity for analytes. To expand the application of nanoporous sensors, real-time and fast detection of targets, all within a portable device, is highly desired for nanopore-based sensors. In addition, to improve the accuracy of the output signal, more appropriate readout methods also need to be explored.

Tunable Nanopore Arrays as the Basis for Ionic Circuits.

There has been considerable interest in preparing ionic circuits capable of manipulating ionic and molecular transport in a solution. This direction of research is inspired by biological systems where multiple pores with different functionalities embedded in a cell membrane transmit external signals and underlie all physiological processes. In this manuscript, we describe the modeling of ion transport through small arrays of nanopores consisting of 3, 6, and 9 nanopores and an integrated gate electrode placed on the membrane surface next to one pore opening.

Ionic amplifying circuits inspired by electronics and biology.

Integrated circuits are present in all electronic devices, and enable signal amplification, modulation, and relay. Nature uses another type of circuits composed of channels in a cell membrane, which regulate and amplify transport of ions, not electrons and holes as is done in electronic systems. Here we show an abiotic ionic circuit that is inspired by concepts from electronics and biology.

An assessment of the limits of detection, sensitivity and specificity of three devices for public health-based drug checking of fentanyl in street-acquired samples.

Background: Fentanyl has caused rapid increases in US and Canadian overdose deaths, yet its presence in illicit drugs is often unknown to consumers. This study examined the validity in identifying the presence of fentanyl of three portable devices that could be used in providing drug checking services and drug supply surveillance: fentanyl test strips, a hand-held Raman Spectrometer, and a desktop Fourier-Transform Infrared Spectrometer.

Methods: In Fall 2017, we first undertook an assessment of the limits of detection for fentanyl, then tested the three devices' sensitivity and specificity in distinguishing fentanyl in street-acquired drug samples.

Electrokinetic Phenomena in Organic Solvents.

Solid/liquid interfaces play a key role in separation processes, energy storage devices, and transport in nanoscale systems. Nanopores and mesopores with well-defined geometry and chemical characteristics have been a valuable tool to unravel electrochemical properties of interfaces, but the majority of studies have been focused on aqueous solutions. Here, we present experiments and numerical modeling aimed at characterizing effective surface charge of polymer pores in mixtures of water and alcohols as well as in propylene carbonate and acetone.

Viscosity and Conductivity Tunable Diode-like Behavior for Meso- and Micropores.

Rectifying pores, which transport ions mainly in one direction blocking the ionic flow in the other, were shown to be important in the preparation of chemical sensors, components of ionic circuits, and mimics of biological channels. Ionic rectification has been shown with various engineered systems, but pores with similar opening diameters often rectify to a various uncontrolled extent. In this Letter we present a system of single meso-pores, whose current-voltage curves and rectification can be tuned with great precision via viscosity and conductivity gradients of solutions placed on both sides of the membrane.

Influence of foot posture on the functioning of the windlass mechanism.

The absence of a functioning windlass mechanism may delay re-supination of the foot during locomotion and put excess stress on the mid-tarsal joint and soft tissues of the foot. The purpose of this study was to describe the foot posture of individuals that have an impaired or absent windlass mechanism. Forty-seven individuals (34 females and 13 males) with a mean age of 26 years were recruited to participate in this study.