Contralateral noise has possible asymmetric frequency-sensitive effect on the 2F1-F2 otoacoustic emission in humans.

Contralateral acoustic stimulation has been shown to produce a suppressive effect on the 2F1-F2 distortion-product otoacoustic emission (DPOAE). According to reports by other studies, there is a frequency-specific suppressive region between 1 and 2kHz when the contralateral broadband or narrowband noise stimulation contains energy close to or near the F2 frequencies in that region. In general the broader the bandwidth of the noise stimulation, the greater is the suppressive effect.