Publications by authors named "Rachel Levi"
Background: Fecal calprotectin (FC) is a marker of mucosal inflammation in inflammatory bowel disease (IBD). We aimed to assess the effect of anti-tumor necrosis factor alpha (TNFα) therapy on FC levels in children with IBD.
Methods: The medical records of pediatric patients treated with anti-TNFα agents (2015-2020) were reviewed retrospectively.
High anti-TNFα Concentrations Are Not Associated With More Adverse Events in Pediatric Inflammatory Bowel Disease.
J Pediatr Gastroenterol Nutr
December 2021
Article Synopsis
- * A study reviewed medical records of 135 pediatric patients on anti-TNFα from 2015 to 2020 to evaluate the link between drug levels and side effects.
- * Results showed that although 37% of patients experienced adverse events, higher drug levels did not correlate with increased side effects, while younger age was associated with a higher incidence of these events (except for liver enzyme increases).
Paediatric Colonoscopy Direct Observation of Procedural Skills: Evidence of Validity and Competency Development.
J Pediatr Gastroenterol Nutr
July 2019
Introduction: The paediatric series of direct observation of procedural skills (DOPS) were introduced into the UK national endoscopy training curriculum in 2016, but lack validity evidence. We aimed to present validity evidence for paediatric colonoscopy DOPS and study competency development in a national trainee cohort.
Methods: This prospective UK-wide study analysed formative paediatric colonoscopy DOPS which were submitted to the e-Portfolio between 2016 and 2018.
Validity Evidence for Direct Observation of Procedural Skills in Paediatric Gastroscopy.
J Pediatr Gastroenterol Nutr
December 2018
Objectives: Direct observation of procedural skills (DOPS) are competence-assessment tools in endoscopy. Formative paediatric gastroscopy DOPS were implemented into the UK curriculum in 2016 but lack validity evidence; we aimed to assess validity evidence using a recognised contemporary validity framework.
Methods: We performed a prospective UK-wide analysis of formative paediatric gastroscopy DOPS submitted to the e-Portfolio over 1 year.
Mid-life onset male dysthymic disorder (DD) seems to be a distinct clinical condition with limited therapeutic options. Testosterone replacement is mood-enhancing and has been proposed as an antidepressant therapy, though this strategy has received limited systematic study. We therefore conducted a six-week double-blind placebo-controlled clinical trial in 23 men with DD and with low or low-normal testosterone (T) level (i.
View Article and Find Full Text PDFPurpose Of Review: The intestine has traditionally been assumed to process food by digestion and absorption. The possibility that the intestine or other genes in the body respond to diet has only slowly been appreciated.
Recent Findings: This review examines recent evidence that nutrients act on genes in the intestine and in distant sites such as the brain, liver, and skeletal muscle.