Publications by authors named "Rachel L Rodeghero"
The contribution of the proinflammatory cytokines IFN-gamma and IL-17 to the pathogenesis of experimental arthritis is controversial. In proteoglycan (PG)-induced arthritis (PGIA), severe arthritis is dependent on the production of IFN-gamma, whereas IL-17 is dispensable. In collagen-induced arthritis and Ag-induced arthritis, although high levels of IFN-gamma are secreted, disease is exacerbated in IFN-gamma or IFN-gamma receptor-deficient mice due to the ability of IFN-gamma to suppress IL-17 expression.
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- - The study investigates the role of the CCR5 receptor and its ligands in inflammation, specifically in the context of arthritis, to understand whether CCR5 acts as a proinflammatory or anti-inflammatory agent.
- - Researchers induced arthritis in both wild-type and CCR5-deficient mice and monitored disease progression while also using a CCR5-blocking treatment to assess its effects on inflammation and cytokine levels.
- - Findings revealed that lack of CCR5 led to worsened arthritis symptoms, indicating that CCR5 is crucial for managing inflammation resolution in arthritis models, as it helps regulate levels of CCL5, a pro-inflammatory chemokine.