Publications by authors named "Rachel L Maus"
Multiplex immunofluorescence (MxIF) images provide detailed information of cell composition and spatial context for biomedical research. However, compromised data quality could lead to research biases. Comprehensive image quality checking (QC) is essential for reliable downstream analysis.
View Article and Find Full Text PDFThrough our involvement in KEYNOTE-059, we unexpectedly observed durable responses in two patients with metastatic gastroesophageal adenocarcinoma (mGEA) who received ramucirumab (anti-VEGFR-2)/paclitaxel after immune checkpoint inhibition (ICI). To assess the reproducibility of this observation, we piloted an approach to administer ramucirumab/paclitaxel after ICI in more patients, and explored changes in the immune microenvironment. Nineteen consecutive patients with mGEA received ICI followed by ramucirumab/paclitaxel.
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- Immunosuppression in glioblastoma (GBM) hinders effective immunotherapy, primarily due to the role of GBM-derived immunosuppressive monocytes and the PD-L1 checkpoint molecule expressed by GBM cells and extracellular vesicles (EVs).
- Research involved conditioning normal monocytes with GBM EVs to observe the formation of immunosuppressive monocytes and their impact on T-cell proliferation, using various methods to manipulate PD-L1 expression.
- Results showed that while GBM EVs do not directly inhibit T-cell activation, they do promote immunosuppressive monocyte populations that, in turn, suppress T-cell proliferation, highlighting the complexity of signaling mechanisms involved in this immunosuppression process.
Article Synopsis
- A child had weak muscles, was behind in development, and had an unusual brain scan.
- Scientists found a new change in a gene called GFAP, labeled p.R376W, that might cause problems.
- They decided that this change is dangerous and likely causes a disease called Alexander disease.
Aiming to decipher immunological mechanisms of the autoimmune disorder alopecia areata (AA), we hypothesized that interleukin-6 (IL-6) might be associated with juvenile-onset AA, for which there is currently no experimental model. Upon intramuscular transgenesis to overexpress IL-6 in pregnant female C57BL/6 (B6) mice, we found that the offspring displayed an initial normal and complete juvenile hair growth cycle, but developed alopecia around postnatal day 18. This alopecia was patchy and reversible (non-scarring) and was associated with upregulation of Ulbp1 expression, the only mouse homolog of the human AA-associated ULBP3 gene.
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