Publications by authors named "Rachel Kuehn"
Background: Head and neck squamous cell carcinoma (HNSCC) presents significant treatment challenges, particularly in cases unrelated to human papillomavirus (HPV). The chemokine receptor CXCR4, interacting with its ligand CXCL12, plays a crucial role in tumor proliferation, metastasis, and treatment resistance. This study explores the therapeutic potential of engineered monomeric and dimerized CXCL12 variants (CXCL12 and CXCL12, respectively) in HNSCC and evaluates potential additive effects when combined with radiation therapy.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on HPV-negative head and neck squamous cell carcinoma (HNSCC), which is resistant to treatment and has limited immunotherapy responses.
- Researchers extracted tumor-infiltrating lymphocytes (TILs) from 31 HNSCC patients and analyzed their function and cancer-targeting ability.
- Results revealed that TILs can still function effectively despite expressing exhaustion markers, indicating the potential for developing personalized T cell therapies for HNSCC patients.
Objectives: Human Papillomavirus (HPV)-negative head and neck cancer (HNC) is an aggressive malignancy with a poor prognosis. To improve outcomes, we developed a novel liposomal targeting system embedded with 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH), a chlorin-based photosensitizer. Upon exposure to 660 nm light, HPPH phototriggering generates reactive oxygen species.
View Article and Find Full Text PDF