Publications by authors named "Rachel Krabacher"
Article Synopsis
- A new high-throughput pipeline was developed for quickly designing and screening biorecognition elements (BREs) targeting the SARS-CoV-2 spike protein to support diagnostic tests and antiviral treatments.
- The pipeline combines computer-aided design of a peptide library with microarray screening, successfully identifying four peptides that strongly bind to the SARS-CoV-2 spike protein.
- One of these peptides was integrated into an electrochemical sensor, achieving effective detection of the S protein in saliva, showcasing the potential for this approach in future viral threat responses.
Because of the sharp distance dependence of surface-enhanced Raman spectroscopy (SERS), analyte molecules that do not exhibit strong affinity for Au/Ag often elude detection. New methods of integrating such analytes with SERS substrates are required to circumvent this limitation and expand the sensitivity of SERS to new molecules and applications. We communicate here a solution-phase, capture agent-free method of aggregating Au nanospheres in the presence of five neurotransmitters (dopamine, epinephrine, norepinephrine, serotonin, and histamine) and preventing sedimentation by encapsulating the aggregated nanospheres with polyvinylpyrrolidone, thereby trapping the neurotransmitters in close proximity to the Au nanospheres and enabling SER detection.
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