Naloxegol versus Methylnaltrexone for Opioid-Induced Constipation in Critically Ill Patients.

Background: Constipation impacts 58% to 83% of critically ill patients and is associated with increased time on mechanical ventilation, delirium, and increased length of stay (LOS) in the intensive care unit (ICU).

Objective: The purpose of this study was to evaluate the efficacy of enteral naloxegol (NGL) versus subcutaneous methylnaltrexone (MNTX) for the management of opioid-induced constipation (OIC) in critically ill patients.

Methods: A retrospective analysis was conducted on adult patients admitted to the ICU who received a parenteral opioid infusion for at least 4 hours and experienced no bowel movement (BM) within the 48-hour period preceding the administration of NGL or MNTX.

Relationships are the key to a successful publicly funded homebirth program, a qualitative study.

Background: In Australia, publicly-funded homebirth is a relatively new option for women and their families. Two years after the inception of two publicly funded homebirth services in Victoria in 2009, a study found that midwives' experiences were more positive than doctors. There is no recent evidence on the perspectives of midwives and doctors of publicly-funded homebirth programs.

Ten years of a publicly funded homebirth service in Victoria: Maternal and neonatal outcomes.

Background: Rates of homebirth in Australia remain low, at less than 0.3% of all births.

Aims: To report maternal and neonatal outcomes of ten years of a publicly funded homebirth service, 2009-2019.