Publications by authors named "Rachel Kirven"
Article Synopsis
- - The study aimed to develop a deep learning segmentation model to locate basal cell carcinoma (BCC) on Mohs surgery (MMS) frozen section slides, which is crucial for precise tumor removal.
- - Researchers utilized a dataset of 348 tissue slides and trained the model using the Ultralytics YOLOv8 framework, achieving varying sensitivity and specificity rates by BCC subtype.
- - Results indicated good overall performance with a sensitivity of 71% and specificity of 75%, but highlighted the need for improved performance metrics for clinical application in segmentation studies.
Article Synopsis
- - DRESS syndrome is a severe medication reaction that includes symptoms like rash, fever, and organ dysfunction, making it important to identify the drugs causing it and monitor the disease to avoid serious damage.
- - Past studies haven't looked closely at how certain medications, like vancomycin, relate to lab results in DRESS, which limits effective monitoring.
- - Our research shows a significant difference in when peak AST levels occur in patients with vancomycin-triggered DRESS compared to other causes, highlighting AST's potential as a key tool for diagnosis and monitoring in these cases.
Background: Perinatal palliative care can offer compassionate support to families following diagnosis of a life-limiting illness, to enable them to make valued choices and the most of the time that they have with their newborn. However, home birth is usually only offered in low-risk pregnancies.
Case: A couple who received an antenatal diagnosis of hypoplastic left heart syndrome and who had made a plan to provide palliative care to their baby after birth requested the option of a home birth.
Steven Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), grouped together under the terminology of epidermal necrolysis (EN), are a spectrum of life-threatening dermatologic conditions. A lack of standardization and validation for existing endpoints has been identified as a key barrier to the comparison of these therapies and development of evidenced-based treatment. Following PRISMA guidelines, we conducted a systematic review of prospective studies involving systemic or topical treatments for EN, including dressing and ocular treatments.
View Article and Find Full Text PDFBackground: Cellulitis is a significant public health burden and lacks a gold standard for diagnosis. Up to 1/3 of patients are incorrectly diagnosed. The skin biopsy has been proposed as the gold standard.
View Article and Find Full Text PDFSymmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is classically considered a low-risk, self-limiting eruption lacking systemic manifestations and sparing facial and mucosal areas. We present 7 inpatients meeting diagnostic criteria for SDRIFE with concomitant systemic manifestations ± high-risk facial involvement acutely after antibiotic exposure (mean latency 6.71 days).
View Article and Find Full Text PDF