Acetylcholine Boosts Dendritic NMDA Spikes in a CA3 Pyramidal Neuron Model.

Acetylcholine has been proposed to facilitate the formation of memory ensembles within the hippocampal CA3 network, by enhancing plasticity at CA3-CA3 recurrent synapses. Regenerative NMDA receptor (NMDAR) activation in CA3 neuron dendrites (NMDA spikes) increase synaptic Ca influx and can trigger this synaptic plasticity. Acetylcholine inhibits potassium channels which enhances dendritic excitability and therefore could facilitate NMDA spike generation.

Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits.

In the hippocampus, episodic memories are thought to be encoded by the formation of ensembles of synaptically coupled CA3 pyramidal cells driven by sparse but powerful mossy fiber inputs from dentate gyrus granule cells. The neuromodulators acetylcholine and noradrenaline are separately proposed as saliency signals that dictate memory encoding but it is not known if they represent distinct signals with separate mechanisms. Here, we show experimentally that acetylcholine, and to a lesser extent noradrenaline, suppress feed-forward inhibition and enhance Excitatory-Inhibitory ratio in the mossy fiber pathway but CA3 recurrent network properties are only altered by acetylcholine.

Gender Differences in Psychosocial Predictors of Attitudes Toward Reporting Child Sexual Abuse in the United Kingdom.

There is a dearth of research investigating psychosocial correlates of attitudes toward reporting child sexual abuse in males and females and a lack of such studies drawing on participants from the United Kingdom. Therefore, the main objective of this article is to examine gender differences in social and psychological predictors of attitudes toward reporting child sexual abuse. Participants drawn from the United Kingdom general population were recruited via an opportunistic sampling method.